Kothalawala Sukitha Geethma, Zhang Jun, Wang Yue, Yu Chengzhong
Australian Institute of Bioengineering and Nanotechnology, University of Queensland, Brisbane, QLD 4072, Australia.
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.
Antibiotics (Basel). 2021 Oct 29;10(11):1324. doi: 10.3390/antibiotics10111324.
Oregano essential oil (OEO) is a natural compound consisting of potent antibiotic molecules. Its volatility is the major obstacle against the transportation and anti-bacterial performance. In this work, submicron-sized vermiculite (SMV) particles were prepared from Australian vermiculite clay by ball milling, and tested as a potential particulate-carrier for OEO. The loading of OEO by SMV can be easily achieved by mechanical mixing. Compared to raw vermiculite and free OEO, the OEO-loaded SMV displayed sustained isothermal release behaviour of OEO and demonstrated enhanced antibacterial performance in in vitro antibacterial tests against () and (). This study provides a facile and commercially viable approach in designing advantageous carriers for volatile actives in antimicrobial applications.
牛至精油（OEO）是一种由强效抗生素分子组成的天然化合物。其挥发性是阻碍其运输和抗菌性能的主要障碍。在这项工作中，通过球磨法从澳大利亚蛭石粘土制备了亚微米级蛭石（SMV）颗粒，并将其作为OEO的潜在颗粒载体进行了测试。通过机械混合可以轻松实现SMV对OEO的负载。与原始蛭石和游离OEO相比，负载OEO的SMV表现出OEO的持续等温释放行为，并在针对（）和（）的体外抗菌测试中表现出增强的抗菌性能。本研究为抗菌应用中挥发性活性物质设计有利载体提供了一种简便且具有商业可行性的方法。
