Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Department of Neurology, Case Western Reserve University, Cleveland, OH, USA.
Neuromodulation. 2021 Feb;24(2):248-258. doi: 10.1111/ner.13350. Epub 2021 Jan 3.
Subthalamic deep brain stimulation (DBS) is an established therapy for Parkinson's disease. Connectomic DBS modeling is a burgeoning subfield of research aimed at characterizing the axonal connections activated by DBS. This article describes our approach and methods for evolving the StimVision software platform to meet the technical demands of connectomic DBS modeling in the subthalamic region.
StimVision v2 was developed with Visualization Toolkit (VTK) libraries and integrates four major components: 1) medical image visualization, 2) axonal pathway visualization, 3) electrode positioning, and 4) stimulation calculation.
StimVision v2 implemented two key technological advances for connectomic DBS analyses in the subthalamic region. First was the application of anatomical axonal pathway models to patient-specific DBS models. Second was the application of a novel driving-force method to estimate the response of those axonal pathways to DBS. Example simulations with directional DBS electrodes and clinically defined therapeutic DBS settings are presented to demonstrate the general outputs of StimVision v2 models.
StimVision v2 provides the opportunity to evaluate patient-specific axonal pathway activation from subthalamic DBS using anatomically detailed pathway models and electrically detailed electric field distributions with interactive adjustment of the DBS electrode position and stimulation parameter settings.
丘脑底核深部脑刺激（DBS）是治疗帕金森病的一种已确立的疗法。连接组学 DBS 建模是一个新兴的研究领域，旨在描述 DBS 激活的轴突连接。本文介绍了我们的方法和方法，用于发展 StimVision 软件平台，以满足在丘脑底核区域进行连接组学 DBS 建模的技术需求。
StimVision v2 是使用可视化工具包（VTK）库开发的，它集成了四个主要组件：1）医学图像可视化，2）轴突通路可视化，3）电极定位，4）刺激计算。
StimVision v2 为丘脑底核的连接组学 DBS 分析实施了两项关键技术进步。首先是将解剖学轴突通路模型应用于患者特定的 DBS 模型。其次是应用一种新的驱动力方法来估计这些轴突通路对 DBS 的反应。使用定向 DBS 电极和临床定义的治疗性 DBS 设置进行了示例模拟，以展示 StimVision v2 模型的一般输出。
StimVision v2 提供了使用解剖详细的通路模型和电详细的电场分布评估来自丘脑底核 DBS 的患者特异性轴突通路激活的机会，同时可以交互式调整 DBS 电极位置和刺激参数设置。
