Hasegawa Daisuke, Asada Rikako, Miura Takayuki
Laboratory of Veterinary Clinical Neurology, Graduate School of Nippon Veterinary and Life Science University, Tokyo, Japan.
Veterinary Medical Teaching Hospital, Nippon Veterinary and Life Science University, Tokyo, Japan.
Front Vet Sci. 2025 Aug 15;12:1649816. doi: 10.3389/fvets.2025.1649816. eCollection 2025.
Corpus callosotomy (CC) is a surgical procedure for palliative epilepsy surgery targeting generalized seizures. In humans, total CC (TCC) is primarily performed in pediatric patients, whereas anterior CC is typically performed in adult patients to avoid postoperative disconnection (split-brain) syndrome, even though the antiseizure effect is inferior to TCC. In dogs, TCC may be more favorable; however, approaching and dividing the rostral part of the corpus callosum (genu) through a previously described bilateral rostrotentorial (dorsal) approach is challenging, particularly in meso- and dolichocephalic and/or large-breed dogs. This approach also risks damaging the rostral cerebral arteries that run along the rostral edge of the genu. Based on our experience, approaching and dividing the genu is easier, safer, and more reliable using the transfrontal approach. This report introduces the rostral CC (RCC) procedure via the transfrontal approach and presents three cases that underwent either transfrontal RCC combined with the dorsal approach to complete TCC or standalone RCC. Although the antiseizure efficacy of RCC alone remains unclear in dogs, this procedure may be useful for completing TCC.
胼胝体切开术（CC）是一种针对全身性癫痫发作的姑息性癫痫手术。在人类中，完全胼胝体切开术（TCC）主要用于儿科患者，而前部胼胝体切开术通常用于成年患者，以避免术后分离（裂脑）综合征，尽管其抗癫痫效果不如TCC。在犬类中，TCC可能更有利；然而，通过先前描述的双侧额颞（背侧）入路接近并分割胼胝体的前部（膝部）具有挑战性，尤其是在中头型和长头型及/或大型犬中。这种入路还存在损伤沿膝部前缘走行的前部脑动脉的风险。根据我们的经验，使用经额入路接近并分割膝部更容易、更安全且更可靠。本报告介绍了经额入路的前部胼胝体切开术（RCC）手术，并展示了三例接受经额RCC联合背侧入路完成TCC或单独RCC的病例。尽管单独RCC在犬类中的抗癫痫疗效尚不清楚，但该手术可能有助于完成TCC。
