小胶质细胞和星形胶质细胞在异常铜稳态假说背景下的阿尔茨海默病。
Microglia and Astrocytes in Alzheimer's Disease in the Context of the Aberrant Copper Homeostasis Hypothesis.
机构信息
Department of Biochemistry, AIIMS, Kalyani 741245, West Bengal, India.
Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research (MMIMSR), Maharishi Markandeshwar University (MMU), Mullana, Ambala 133207, Haryana, India.
出版信息
Biomolecules. 2021 Oct 28;11(11):1598. doi: 10.3390/biom11111598.
Evidence of copper's (Cu) involvement in Alzheimer's disease (AD) is available, but information on Cu involvement in microglia and astrocytes during the course of AD has yet to be structurally discussed. This review deals with this matter in an attempt to provide an updated discussion on the role of reactive glia challenged by excess labile Cu in a wide picture that embraces all the major processes identified as playing a role in toxicity induced by an imbalance of Cu in AD.
有证据表明铜（Cu）参与了阿尔茨海默病（AD），但关于 AD 过程中 Cu 对小胶质细胞和星形胶质细胞的影响的信息尚未从结构上进行讨论。本综述探讨了这一问题，试图提供一个更新的讨论，即过剩的不稳定 Cu 对反应性神经胶质的作用，这个广泛的观点包括了所有被认为在 AD 中 Cu 失衡诱导的毒性中起作用的主要过程。
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