Center for Research on Infectious Diseases, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico.
Department of Basic Research, Instituto Nacional de Cancerología, Mexico City 14080, Mexico.
Biomolecules. 2021 Nov 17;11(11):1709. doi: 10.3390/biom11111709.
Human encodes an AT-hook transcription factor whose expression participates in various cellular processes. We conducted a scoping review on the literature regarding the functional role of AKNA according to the evidence found in human and in vivo and in vitro models, stringently following the "PRISMA-ScR" statement recommendations.
We undertook an independent PubMed literature search using the following search terms, AKNA OR AKNA ADJ gene OR AKNA protein, human OR AKNA ADJ functions. Observational and experimental articles were considered. The selected studies were categorized using a pre-determined data extraction form. A narrative summary of the evidence was produced.
AKNA modulates the expression of CD40 and CD40L genes in immune system cells. It is a negative regulator of inflammatory processes as evidenced by knockout mouse models and observational studies for several autoimmune and inflammatory diseases. Furthermore, AKNA contributes to the de-regulation of the immune system in cancer, and it has been proposed as a susceptibility genetic factor and biomarker in CC, GC, and HNSCC. Finally, AKNA regulates neurogenesis by destabilizing the microtubules dynamics.
Our results provide evidence for the role of AKNA in various cellular processes, including immune response, inflammation, development, cancer, autoimmunity, and neurogenesis.
人类编码一个 AT 钩转录因子，其表达参与各种细胞过程。我们根据在人体和体内及体外模型中发现的证据，对 AKNA 的功能作用进行了文献范围的综述，严格遵循“PRISMA-ScR”声明建议。
我们使用以下搜索词在独立的 PubMed 文献搜索中进行搜索，AKNA 或 AKNA 基因或 AKNA 蛋白，人类或 AKNA 功能。观察性和实验性文章都被考虑。使用预先确定的数据提取表格对选定的研究进行分类。对证据进行了叙述性总结。
AKNA 调节免疫系统细胞中 CD40 和 CD40L 基因的表达。有证据表明，AKNA 是一种负调控炎症过程的因子，其通过敲除小鼠模型和几种自身免疫和炎症性疾病的观察性研究得到证实。此外，AKNA 有助于癌症中免疫系统的失调，并且已被提议作为 CC、GC 和 HNSCC 的易感性遗传因素和生物标志物。最后，AKNA 通过使微管动力学不稳定来调节神经发生。
我们的结果提供了 AKNA 在各种细胞过程中发挥作用的证据，包括免疫反应、炎症、发育、癌症、自身免疫和神经发生。
