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来自（帕胡罗）的白蛋白作为多功能肽的一个有前景的来源。

Albumin from (Pajuro) as a Promising Source of Multifunctional Peptides.

作者信息

Palma-Albino Cleni, Intiquilla Arturo, Jiménez-Aliaga Karim, Rodríguez-Arana Nathaly, Solano Estela, Flores Eduardo, Zavaleta Amparo Iris, Izaguirre Víctor, Hernández-Ledesma Blanca

机构信息

Grupo de Investigación BIOMIAS, Departament of Biochemistry, Facultad de Farmacia y Bioquímica, Universidad Nacional Mayor de San Marcos, Jr. Puno 1002, Lima 4559, Peru.

Departamento de Ciencia de los Alimentos y Tecnología Química, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santos Dumont 946, Santiago de Chile 8380492, Chile.

出版信息

Antioxidants (Basel). 2021 Oct 28;10(11):1722. doi: 10.3390/antiox10111722.

DOI:10.3390/antiox10111722
PMID:34829593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8615073/
Abstract

Multifunctional peptides, capable of acting on different body systems through multiple mechanisms of action, offer many advantages over monofunctional peptides, including lower adverse side effects and costs. (pajuro) is a legume with a large number of high-quality proteins, of which their potential as a source of antioxidant peptides has been recently reported. In this study, the behavior of these proteins under a sequential enzymatic hydrolysis with digestive and microbial enzymes was investigated by evaluating the multi-functionality of the hydrolyzates. The albumin hydrolyzates obtained after the action of pepsin, pancreatin, and Alcalase showed antioxidant, angiotensin-converting enzyme (ACE), α-amylase, α-glucosidase, and dipeptidyl peptidase (DPP)-IV inhibitory activities. The radical scavenging properties of the hydrolyzate could be responsible for the potent protective effects observed in FeSO-induced neuroblastoma cells. The findings support the role of pajuro protein as an ingredient of functional foods or nutraceuticals for health promotion and the prevention of oxidative stress, hypertension, and metabolic alteration-associated chronic diseases.

摘要

多功能肽能够通过多种作用机制作用于不同的身体系统，与单功能肽相比具有许多优势，包括更低的副作用和成本。（pajuro）是一种含有大量优质蛋白质的豆类，最近有报道称其作为抗氧化肽来源的潜力。在本研究中，通过评估水解产物的多功能性，研究了这些蛋白质在消化酶和微生物酶的顺序酶解作用下的行为。胃蛋白酶、胰酶和碱性蛋白酶作用后获得的白蛋白水解产物表现出抗氧化、血管紧张素转换酶（ACE）、α-淀粉酶、α-葡萄糖苷酶和二肽基肽酶（DPP）-IV抑制活性。水解产物的自由基清除特性可能是在硫酸亚铁诱导的神经母细胞瘤细胞中观察到的强大保护作用的原因。这些发现支持了pajuro蛋白作为功能性食品或营养保健品成分在促进健康以及预防氧化应激、高血压和代谢改变相关慢性病方面的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3d/8615073/367aa3a875c0/antioxidants-10-01722-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3d/8615073/eda401481104/antioxidants-10-01722-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3d/8615073/8631044931eb/antioxidants-10-01722-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3d/8615073/27c9df4beb5a/antioxidants-10-01722-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3d/8615073/367aa3a875c0/antioxidants-10-01722-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3d/8615073/eda401481104/antioxidants-10-01722-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3d/8615073/8631044931eb/antioxidants-10-01722-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3d/8615073/27c9df4beb5a/antioxidants-10-01722-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb3d/8615073/367aa3a875c0/antioxidants-10-01722-g004.jpg

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