Di Filippo Paola, Russo Daniele, Attanasi Marina, Di Pillo Sabrina, Chiarelli Francesco
Department of Pediatrics, University of Chieti, 66100 Chieti, Italy.
Center of Excellence on Aging, University of Chieti, 66100 Chieti, Italy.
Biomedicines. 2021 Nov 4;9(11):1615. doi: 10.3390/biomedicines9111615.
Atopic dermatitis and urticaria are two invalidating skin disorders that are very common in children. Recent advances in the understanding of their specific intracellular molecular pathways have permitted the development of precise biological molecules, targeting inflammatory mediators and arresting the pathogenetic pathways of skin diseases. Many biologics with promising results have been studied, although few are currently approved in children. In this review, we aim to provide the latest evidence about the use, indications, efficacy and safety of biologic therapies to treat atopic dermatitis and chronic urticaria in children and adolescents.
特应性皮炎和荨麻疹是两种常见于儿童的使人虚弱的皮肤疾病。对其特定细胞内分子途径认识的最新进展使得能够开发出精确的生物分子，这些分子靶向炎症介质并阻断皮肤疾病的发病途径。已经研究了许多有前景的生物制剂，尽管目前在儿童中获批的很少。在本综述中，我们旨在提供关于生物治疗用于治疗儿童和青少年特应性皮炎和慢性荨麻疹的使用、适应症、疗效和安全性的最新证据。
