Wong Pei-Chun, Wang Ren-Yi, Lu Long-Sheng, Wang Wei-Ru, Jang Jason Shian-Ching, Wu Jia-Lin, Su Tai-Yuan, Chang Ling-Hua
Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Department of Orthopedics, Taipei Medical University Hospital, Taipei 11031, Taiwan.
Biomedicines. 2021 Nov 12;9(11):1677. doi: 10.3390/biomedicines9111677.
Bacterial infection remains a great risk in medical implantation surgery. In this paper, we found that degradable metals may be a feasible alternative option of antibacterial implantation materials. It is known that the spalling mechanism of magnesium (Mg) during degradation leads to Mg ions-induced alkaline environment, which is harmful to planktonic bacteria. In this study, we showed that alkaline pH environment is almost harmless to those adhesive bacteria protected in well-formed biofilms. Moreover, experimental results demonstrated that the biofilm formed in the place where Mg spalls are destroyed, releasing the covered bacteria to be planktonic in the alkaline environment. As a result, the colonization of biofilms continues to shrink during the degradation of Mg. It implies that if degradable metal is employed as implantation material, even if bacterial infection occurs, it may be possibly cured without second surgery.
细菌感染在医学植入手术中仍然是一个巨大的风险。在本文中，我们发现可降解金属可能是抗菌植入材料的一种可行替代选择。众所周知，镁（Mg）在降解过程中的剥落机制会导致镁离子诱导碱性环境，这对浮游细菌是有害的。在本研究中，我们表明碱性pH环境对那些在结构良好的生物膜中受到保护的黏附细菌几乎无害。此外，实验结果表明，在镁剥落的地方形成的生物膜被破坏，使被覆盖的细菌在碱性环境中变为浮游状态。结果，在镁降解过程中生物膜的定植持续缩小。这意味着如果将可降解金属用作植入材料，即使发生细菌感染，也可能无需二次手术即可治愈。
