CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, CAS Center for Excellence in Nanoscience, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
Nanoscale. 2018 Feb 8;10(6):2711-2714. doi: 10.1039/c7nr08844b.
Biomedical materials, such as orthopedic biomaterials, have a great impact on improving life quality and self-esteem of human beings. However, the usage of fixed appliances during dental treatment often increases the difficulty of oral cleaning and enlarges the adhesion opportunity of oral bacteria. Furthermore, the existing anti-adhesion coatings, such as polyethylene glycol derivatives and zwitterionic polymers, have not been universally accepted in the oral environment due to their intrinsic problems. Herein, inspired by the anti-adhesion capability of bovine serum albumin, we report a facile protein-based anti-bacterial surface, showing excellent anti-adhesion performance toward oral bacteria. This protein-mediated anti-adhesion strategy may provide a promising clue for developing new anti-bacterial biomaterials, such as dental fixed appliances, restorative materials and medical mouthwashes.
生物医学材料，如骨科生物材料，对提高人类的生活质量和自尊心有很大的影响。然而，在牙齿治疗过程中使用固定器械往往会增加口腔清洁的难度，并增加口腔细菌的黏附机会。此外，由于内在问题，现有的抗黏附涂层，如聚乙二醇衍生物和两性离子聚合物，在口腔环境中尚未被普遍接受。在此，受牛血清白蛋白抗黏附能力的启发，我们报道了一种简便的基于蛋白质的抗菌表面，对口腔细菌表现出优异的抗黏附性能。这种蛋白质介导的抗黏附策略可能为开发新的抗菌生物材料，如牙科固定器械、修复材料和医用漱口水，提供有前途的线索。
