Rahim Muhammad Imran, Eifler Rainer, Rais Bushra, Mueller Peter P
Helmholtz Centre for Infection Research, Inhoffenstrasse 7, Braunschweig, 38124, Germany.
Institute of Materials Science, Leibniz University Hannover, an Der Universität 2, Garbsen, 30823, Germany.
J Biomed Mater Res A. 2015 Nov;103(11):3526-32. doi: 10.1002/jbm.a.35503. Epub 2015 May 24.
Magnesium alloys are presently investigated as potential medical implant materials for temporary applications. Magnesium has been reported to have antibacterial activities and could therefore be used to prevent antibiotic treatment-resistant bacterial implant infections. For characterizing the effects of magnesium on infectious bacteria, bioluminescent S. aureus or P. aeruginosa were employed. The proliferation of both types of bacteria was suppressed in the presence of metallic magnesium and also in aqueous magnesium corrosion extracts. Of the two soluble corrosion products, magnesium ions were well tolerated while antibacterial activities correlated with increased pH levels of the supernatants. The alkaline pH alone was sufficient for the antibacterial effects which were completely abolished when the pH of the corrosion supernatants was neutralized. These results demonstrate that pH increases are necessary and sufficient for the antibacterial activity of metallic magnesium. In an animal model magnesium implants showed an enhanced but variable resistance to bacterial colonization.
镁合金目前作为临时应用的潜在医用植入材料正在被研究。据报道，镁具有抗菌活性，因此可用于预防对抗生素治疗耐药的细菌植入感染。为了表征镁对感染性细菌的影响，使用了生物发光的金黄色葡萄球菌或铜绿假单胞菌。在金属镁存在的情况下以及在镁腐蚀水提取物中，这两种细菌的增殖均受到抑制。在两种可溶性腐蚀产物中，镁离子具有良好的耐受性，而抗菌活性与上清液pH值的升高相关。仅碱性pH就足以产生抗菌作用，当腐蚀上清液的pH值中和时，抗菌作用完全消失。这些结果表明，pH值升高对于金属镁的抗菌活性是必要且充分的。在动物模型中，镁植入物对细菌定植表现出增强但可变的抵抗力。
