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突变影响水稻中镉和微量元素金属的积累。

Mutation in Affects Cadmium and Micronutrient Metal Accumulation in Rice.

机构信息

Jiangsu Collaborative Innovation Center of Regional Modern Agriculture & Environmental Protection/Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake, Huaiyin Normal University, Huai'an 223300, China.

Jiangsu Key Laboratory of Crop Genetics and Physiology/Jiangsu Key Laboratory of Crop Cultivation and Physiology, Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops, Yangzhou University, Yangzhou 225009, China.

出版信息

Int J Mol Sci. 2021 Nov 22;22(22):12583. doi: 10.3390/ijms222212583.

DOI:10.3390/ijms222212583
PMID:34830475
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8624461/
Abstract

Micronutrient metals, such as Mn, Cu, Fe, and Zn, are essential heavy metals for plant growth and development, while Cd is a nonessential heavy metal that is highly toxic to both plants and humans. Our understanding of the molecular mechanisms underlying Cd and micronutrient metal accumulation in plants remains incomplete. Here, we show that , an -like () family gene in , is preferentially expressed in the root and encodes a protein localized to the cell membrane. The mutation reduces both the uptake and the root-to-shoot translocation of Cd in rice plants. Additionally, the accumulation of micronutrient metals, including Mn, Cu, and Fe, was lower in mutants than in the wildtype plants under normal growth conditions. Moreover, the mutation affects the expression of several heavy metal transporter genes. Protein interaction analyses reveal that rice FWL proteins interact with themselves and one another, and with several membrane microdomain marker proteins. Our results suggest that is involved in Cd and micronutrient metal accumulation in rice. Additionally, rice FWL proteins may form oligomers and some of them may be located in membrane microdomains.

摘要

微量元素金属，如 Mn、Cu、Fe 和 Zn，是植物生长和发育所必需的重金属，而 Cd 是非必需的重金属，对植物和人类都有剧毒。我们对植物中 Cd 和微量元素金属积累的分子机制的理解还不完整。在这里，我们表明， 是 中的一个 - 样 () 家族基因，在根中优先表达，并编码一种定位于细胞膜的蛋白质。 突变减少了水稻植株中 Cd 的吸收和根到茎的转运。此外，在正常生长条件下， 突变体中包括 Mn、Cu 和 Fe 在内的微量元素金属的积累低于野生型植物。此外， 突变影响了几种重金属转运基因的表达。蛋白相互作用分析表明，水稻 FWL 蛋白相互作用，与自身和彼此相互作用，并与几种膜微区标记蛋白相互作用。我们的结果表明， 参与了水稻中 Cd 和微量元素金属的积累。此外，水稻 FWL 蛋白可能形成寡聚体，其中一些可能位于膜微区。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/367f/8624461/13b750102e10/ijms-22-12583-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/367f/8624461/6584b2de7e1e/ijms-22-12583-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/367f/8624461/a3fc9f37582f/ijms-22-12583-g002.jpg
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