Tudoran Cristina, Tudoran Mariana, Lazureanu Voichita Elena, Marinescu Adelina Raluca, Cut Talida Georgiana, Oancea Cristian, Pescariu Silvius Alexandru, Pop Gheorghe Nicusor
Department VII, Internal Medicine II, Discipline of Cardiology, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.
Center of Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, University of Medicine and Pharmacy "Victor Babes" Timisoara, E. Murgu Square, Nr. 2, 300041 Timisoara, Romania.
J Clin Med. 2021 Nov 12;10(22):5272. doi: 10.3390/jcm10225272.
(1) Background: While the COVID-19 pandemic has been persisting for almost 2 years, more and more people are diagnosed with residual complications such as pulmonary hypertension (PH) and right ventricular dysfunction (RVD). This study aims to evaluate the course of PH and borderline PH (BPH) at 3 and 6 months after the acute COVID-19 infection and investigate if there are differences regarding its evolution between the patients from the first three waves of this disease. (2) Methods: We analyzed, by transthoracic echocardiography (TTE), the 3 and 6 months' evolution of the echocardiographically estimated systolic pulmonary artery pressures (esPAP) in 116 patients already diagnosed with PH or BPH due to COVID-19 during the first three subsequent waves of COVID-19. (3) Results: We documented a gradual, statistically significant reduction in esPAP values, but also an improvement of the parameters characterizing RVD after 3 and 6 months ( < 0.001). This evolution was somewhat different between subjects infected with different viral strains and was related to the initial severity of the pulmonary injury and PH (adjusted R = 0.722, < 0.001). (4) Conclusions: PH and RVD alleviate gradually during the recovery after COVID-19, but in some cases, they persist, suggesting the activation of pathophysiological mechanisms responsible for the self-propagation of PH.
(1) 背景：虽然新冠疫情已持续近2年，但越来越多的人被诊断出患有诸如肺动脉高压（PH）和右心室功能障碍（RVD）等残留并发症。本研究旨在评估急性新冠感染后3个月和6个月时PH和临界PH（BPH）的病程，并调查该疾病前三波患者之间在其演变方面是否存在差异。(2) 方法：我们通过经胸超声心动图（TTE）分析了116例在随后的前三波新冠疫情期间因新冠感染已被诊断为PH或BPH的患者的超声心动图估计收缩期肺动脉压（esPAP）在3个月和6个月时的演变情况。(3) 结果：我们记录到esPAP值逐渐出现具有统计学意义的下降，而且在3个月和6个月后，表征RVD的参数也有所改善（<0.001）。这种演变在感染不同病毒株的受试者之间略有不同，并且与肺损伤和PH的初始严重程度有关（调整后的R = 0.722，<0.001）。(4) 结论：新冠感染康复期间，PH和RVD会逐渐缓解，但在某些情况下，它们会持续存在，这表明导致PH自我传播的病理生理机制被激活。
