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激光消融治疗甲状腺乳头状癌复发性淋巴结转移

Laser Ablation Treatment of Recurrent Lymph Node Metastases from Papillary Thyroid Carcinoma.

作者信息

Offi Chiara, Misso Claudia, Antonelli Giovanni, Esposito Maria Grazia, Brancaccio Umberto, Spiezia Stefano

机构信息

Department of Endocrine and Ultrasound-Guided Surgery, Ospedale del Mare, 80147 Naples, Italy.

出版信息

J Clin Med. 2021 Nov 14;10(22):5295. doi: 10.3390/jcm10225295.

Abstract

(1) Background: The incidence of papillary thyroid cancers is increasing. Papillary neoplasm metastasizes to the central and lateral lymph nodes of the neck. The recurrence rate is less than 30%. The gold standard of treatment for lymph node recurrences is surgery, but surgery is burdened by a high rate of complications. Therefore, laser ablation of recurrent lymph nodes has been recognized as an alternative treatment with minimal invasiveness, a low complication rate and a curative effect. (2) Methods: We analyzed 10 patients who underwent a total thyroidectomy and metabolic radiotherapy and who developed a lymph node recurrence in the laterocervical compartment in the following 12-18 months. (3) Results: Patients developed lymph node recurrence at IV and Vb levels in 70% and 30% of cases, respectively. All patients were treated with a single laser ablative session. Hydrodissection was performed in all patients. The energy delivered was 1120 ± 159.3 Joules and 3-4 Watts in 362 ± 45.7 s. No complications were reported. All patients underwent a 6-month follow-up. A volumetric reduction of 40.12 ± 2.2%, 49.1 ± 2.13% and 59.8 ± 3.05%, respectively at 1-, 3- and 6-months of follow-up was reported. (4) Conclusions: At 6 months, a fine needle aspiration was performed, which was negative for malignant cells and negative for a dosage of Thyroglobulin in eluate. The laser ablation is an effective alternative to surgical treatment.

摘要

(1)背景:甲状腺乳头状癌的发病率正在上升。乳头状肿瘤会转移至颈部中央和外侧淋巴结。复发率低于30%。淋巴结复发的治疗金标准是手术,但手术并发症发生率高。因此,复发性淋巴结的激光消融已被公认为是一种微创、低并发症率且有治愈效果的替代治疗方法。(2)方法:我们分析了10例接受全甲状腺切除术和代谢放疗且在随后12至18个月出现颈外侧区淋巴结复发的患者。(3)结果:患者分别在IV级和Vb级出现淋巴结复发的病例占70%和30%。所有患者均接受单次激光消融治疗。所有患者均进行了水分离术。输送的能量为1120±159.3焦耳,在362±45.7秒内为3至4瓦。未报告并发症。所有患者均接受了6个月的随访。随访1个月、3个月和6个月时,报告的体积分别减少了40.12±2.2%、49.1±2.13%和59.8±3.05%。(4)结论:在6个月时进行了细针穿刺抽吸,结果显示洗脱液中恶性细胞为阴性,甲状腺球蛋白剂量为阴性。激光消融是手术治疗的一种有效替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c6e4/8618398/a9911bd3362f/jcm-10-05295-g001.jpg

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