Mølhave Martin, Leth Steffen, Gunst Jesper Damsgaard, Jensen-Fangel Søren, Østergaard Lars, Wejse Christian, Agergaard Jane
Department of Infectious Diseases, Aarhus University Hospital, 8200 Aarhus, Denmark.
Department of Medicine, Regional Hospital Unit West Jutland, 7400 Herning, Denmark.
J Clin Med. 2021 Nov 15;10(22):5298. doi: 10.3390/jcm10225298.
Follow-up studies of COVID-19 survivors have been performed to characterize persistence of long-term symptoms, but data are scarce on one year of follow-up. This study provides data from 48 weeks of follow-up after discharge. All patients discharged from the Department of Infectious Diseases at Aarhus University Hospital, Denmark between 1 March and 1 July 2020 were followed for 48 weeks. In total, 45 of 66 eligible patients were interviewed after 48 weeks. The median age was 57 (IQR 51-70) years, the majority were female (53%) and Caucasian (87%). Median BMI was 28.1 (IQR 24.8-32.6) kg/m. One or more comorbidities were registered among 62% of the patients. In total, 39 out of 45 (87%) interviewed patients reported persistence of at least one symptom 48 weeks after hospitalization with COVID-19. Most frequently reported symptoms were fatigue, dyspnea, and concentration difficulties. This study provides new long-term data following COVID-19, contributing to the accumulating data of COVID-19 sequelae. Many patients suffer long-term sequelae and further research is urgently needed to gain further knowledge of the duration and therapeutic options.
对新冠病毒感染者的随访研究旨在明确长期症状的持续情况，但关于一年随访的数据较少。本研究提供了出院后48周的随访数据。丹麦奥胡斯大学医院传染病科在2020年3月1日至7月1日期间出院的所有患者均接受了48周的随访。48周后，66名符合条件的患者中共有45人接受了访谈。中位年龄为57岁（四分位距51 - 70岁），大多数为女性（53%）且是白种人（87%）。中位体重指数为28.1（四分位距24.8 - 32.6）kg/m²。62%的患者记录有一项或多项合并症。在45名接受访谈的患者中，共有39人（87%）报告在感染新冠病毒住院48周后仍存在至少一种症状。最常报告的症状是疲劳、呼吸困难和注意力不集中。本研究提供了新冠病毒感染后的新长期数据，为新冠病毒后遗症的积累数据做出了贡献。许多患者患有长期后遗症，迫切需要进一步研究以深入了解持续时间和治疗选择。
