Intensive Care Unit, Hospital Universitario Clínico San Cecilio, 18071 Granada, Spain.
School of Nursing, Faculty of Health Sciences, University of Granada, 18071 Granada, Spain.
Int J Environ Res Public Health. 2021 Nov 11;18(22):11817. doi: 10.3390/ijerph182211817.
Therapeutic hypothermia is a treatment used for patients who have suffered cardiorespiratory arrest and remain conscious after the recovery of spontaneous circulation. However, its effectiveness is controversial. The objective of this systematic review is to summarize the scientific evidence available about the effect of therapeutic hypothermia on neurological status and survival in this type of patients.
A primary search in CINAHL, CUIDEN, Pubmed, Web of Science, and Scopus databases was carried out. Randomized clinical trials (RCT) published from 2016 to 2020 were selected.
17 studies were selected for inclusion and most relevant data were extracted. Methodological quality was assessed by the RoB tool.
Although therapeutic hypothermia is a safe technique with few adverse and manageable effects, it has not shown to improve survival rate and neurological status of adult nor pediatric patients. It is possible that its positive effect on neuroprotection could be achieved only by preventing hyperthermia although further investigation is needed.
总结治疗性低温对这类患者神经状态和生存的影响的现有科学证据。
在 CINAHL、CUIDEN、PubMed、Web of Science 和 Scopus 数据库中进行了初步检索。选择了 2016 年至 2020 年发表的随机临床试验 (RCT)。
选择了 17 项研究进行纳入，提取了最相关的数据。使用 RoB 工具评估了方法学质量。
尽管治疗性低温是一种安全的技术，不良反应少且易于处理，但它并未显示出可提高成人和儿科患者的生存率和神经状态。只有通过预防体温过高，才有可能实现其对神经保护的积极影响，但需要进一步研究。
Zotero 插件