Olăreț Elena, Stancu Izabela-Cristina, Iovu Horia, Serafim Andrada
Advanced Polymer Materials Group, University Politehnica of Bucharest, 011061 Bucharest, Romania.
Faculty of Medical Engineering, University Politehnica of Bucharest, 011061 Bucharest, Romania.
Materials (Basel). 2021 Nov 10;14(22):6763. doi: 10.3390/ma14226763.
The ever-growing field of materials with applications in the biomedical field holds great promise regarding the design and fabrication of devices with specific characteristics, especially scaffolds with personalized geometry and architecture. The continuous technological development pushes the limits of innovation in obtaining adequate scaffolds and establishing their characteristics and performance. To this end, computed tomography (CT) proved to be a reliable, nondestructive, high-performance machine, enabling visualization and structure analysis at submicronic resolutions. CT allows both qualitative and quantitative data of the 3D model, offering an overall image of its specific architectural features and reliable numerical data for rigorous analyses. The precise engineering of scaffolds consists in the fabrication of objects with well-defined morphometric parameters (e.g., shape, porosity, wall thickness) and in their performance validation through thorough control over their behavior (in situ visualization, degradation, new tissue formation, wear, etc.). This review is focused on the use of CT in biomaterial science with the aim of qualitatively and quantitatively assessing the scaffolds' features and monitoring their behavior following in vivo or in vitro experiments. Furthermore, the paper presents the benefits and limitations regarding the employment of this technique when engineering materials with applications in the biomedical field.
在生物医学领域具有应用前景的材料领域不断发展，在设计和制造具有特定特性的设备方面，尤其是具有个性化几何形状和结构的支架方面，有着巨大的潜力。持续的技术发展推动了在获得合适支架以及确定其特性和性能方面的创新极限。为此，计算机断层扫描（CT）被证明是一种可靠的、无损的、高性能的机器，能够在亚微米分辨率下进行可视化和结构分析。CT可以提供三维模型的定性和定量数据，给出其特定结构特征的整体图像，并为严格分析提供可靠的数值数据。支架的精确工程包括制造具有明确形态计量参数（如形状、孔隙率、壁厚）的物体，并通过对其行为的全面控制（原位可视化、降解、新组织形成、磨损等）对其性能进行验证。本综述聚焦于CT在生物材料科学中的应用，旨在定性和定量评估支架的特征，并监测其在体内或体外实验后的行为。此外，本文还介绍了在生物医学领域应用的工程材料中使用该技术的优点和局限性。
