Facultad de Medicina Humana, Universidad de San Martín de Porres, Chiclayo, Perú.
Dirección de Investigación, Hospital Regional Lambayeque, Chiclayo, Perú.
Rev Peru Med Exp Salud Publica. 2020 Dec 2;37(3):478-484. doi: 10.17843/rpmesp.2020.373.5275.
To compare the hypoglycemic effect of the aqueous extract of Moringa oleifera (moringa), Smallanthus sonchifolius (yacon) and metformin on Rattus norvegicus, albino variety, with induced diabetes mellitus.
Preclinical, experimental, controlled and randomized study. Diabetes was induced intraperitoneally with a dose of alloxan at 130 mg/kg. A total of 24 male Rattus norvegicus, albino variety, Holfzman strain (6 per group) were used. They were divided as follows: control group (no treatment), metformin group (14 mg/kg), M. oleifera group (200 mg/kg), and S. sonchifolius group (140 mg/kg), treatments were administered via orogastric tube for 15 days. Glycemia levels were determined using an Accu-Chek® Instant electronic glycometer (Roche).
Decreased glycemia was observed in the treatment groups: M. oleifera (p = 0.009), S. sonchifolius (p = 0.002) and metformin (p = 0.002), by 313 mg/dL, 281.5 mg/dL and 415 mg/dL, respectively. When comparing glycemia in the treated and control groups, no difference was observed (P > 0.05) at 24 hours and four days of treatment; while at the eighth (P < 0.05) and fifteenth day (P < 0.01) the treated groups had lower glycemia than the control group, but it was similar among them.
The aqueous extract of S. sonchifolius, M. oleifera, and metformin presented similar hypoglycemic effect in experimental rats with induced diabetes.
比较辣木叶（辣木）、菊薯（雅甘）水提物和二甲双胍对诱导型糖尿病大鼠的降血糖作用。
临床前、实验、对照和随机研究。糖尿病通过腹腔内注射剂量为 130mg/kg 的链脲佐菌素诱导。共使用 24 只雄性白化仓鼠（6 只/组）。它们被分为以下几组：对照组（未治疗）、二甲双胍组（14mg/kg）、辣木叶组（200mg/kg）和菊薯组（140mg/kg），通过口服管饲给药 15 天。使用 Accu-Chek® Instant 电子血糖仪（罗氏）测定血糖水平。
治疗组的血糖水平均降低：辣木叶组（p=0.009）、菊薯组（p=0.002）和二甲双胍组（p=0.002）分别降低 313mg/dL、281.5mg/dL 和 415mg/dL。与对照组相比，治疗 24 小时和 4 天时血糖无差异（P>0.05）；而在治疗第 8 天（P<0.05）和第 15 天（P<0.01）时，治疗组的血糖低于对照组，但它们之间的差异无统计学意义。
菊薯、辣木叶水提物和二甲双胍在诱导型糖尿病大鼠中具有相似的降血糖作用。
