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双蛋白赖氨酸和蛋白N端甲基转移酶METTL13的结构、活性与功能

Structure, Activity and Function of the Dual Protein Lysine and Protein N-Terminal Methyltransferase METTL13.

作者信息

Jakobsson Magnus E

机构信息

Department of Immunotechnology, Lund University, Medicon Village, 22100 Lund, Sweden.

出版信息

Life (Basel). 2021 Oct 21;11(11):1121. doi: 10.3390/life11111121.

DOI:10.3390/life11111121
PMID:34832997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8624817/
Abstract

METTL13 (also known as eEF1A-KNMT and FEAT) is a dual methyltransferase reported to target the N-terminus and Lys55 in the eukaryotic translation elongation factor 1 alpha (eEF1A). METTL13-mediated methylation of eEF1A has functional consequences related to translation dynamics and include altered rate of global protein synthesis and translation of specific codons. Aberrant regulation of METTL13 has been linked to several types of cancer but the precise mechanisms are not yet fully understood. In this article, the current literature related to the structure, activity, and function of METTL13 is systematically reviewed and put into context. The links between METTL13 and diseases, mainly different types of cancer, are also summarized. Finally, key challenges and opportunities for METTL13 research are pinpointed in a prospective outlook.

摘要

METTL13（也称为eEF1A-KNMT和FEAT）是一种双甲基转移酶，据报道它作用于真核翻译延伸因子1α（eEF1A）的N端和赖氨酸55位点。METTL13介导的eEF1A甲基化具有与翻译动力学相关的功能后果，包括整体蛋白质合成速率的改变以及特定密码子的翻译。METTL13的异常调控与多种癌症相关，但具体机制尚未完全明确。在本文中，系统回顾了与METTL13的结构、活性和功能相关的现有文献，并进行了背景阐述。还总结了METTL13与疾病（主要是不同类型癌症）之间的联系。最后，在前瞻性展望中明确了METTL13研究的关键挑战和机遇。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3551/8624817/4a6a992c6f2c/life-11-01121-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3551/8624817/9df0b2ff85ce/life-11-01121-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3551/8624817/ecaa0f15be4c/life-11-01121-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3551/8624817/976ac14d83f1/life-11-01121-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3551/8624817/4a6a992c6f2c/life-11-01121-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3551/8624817/9df0b2ff85ce/life-11-01121-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3551/8624817/930bf55214e5/life-11-01121-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3551/8624817/2cc1fdac8c80/life-11-01121-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3551/8624817/ecaa0f15be4c/life-11-01121-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3551/8624817/976ac14d83f1/life-11-01121-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3551/8624817/802eb9d7976d/life-11-01121-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3551/8624817/4a6a992c6f2c/life-11-01121-g007.jpg

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Discovering the N-Terminal Methylome by Repurposing of Proteomic Datasets.通过重新利用蛋白质组数据集来发现 N 端甲基组。
J Proteome Res. 2021 Sep 3;20(9):4231-4247. doi: 10.1021/acs.jproteome.1c00009. Epub 2021 Aug 12.
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Methyltransferase like 13 mediates the translation of Snail in head and neck squamous cell carcinoma.甲基转移酶样蛋白 13 介导口腔和头颈部鳞状细胞癌中 Snail 的翻译。
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Methyltransferase-like proteins in cancer biology and potential therapeutic targeting.癌症生物学中的甲基转移酶样蛋白及其潜在的治疗靶点。
J Hematol Oncol. 2023 Aug 2;16(1):89. doi: 10.1186/s13045-023-01477-7.
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Special Issue "Structure, Activity, and Function of Protein Methyltransferases".特刊“蛋白质甲基转移酶的结构、活性与功能”
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Int J Oral Sci. 2021 Aug 11;13(1):26. doi: 10.1038/s41368-021-00130-8.
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Multi-omics integration of methyltransferase-like protein family reveals clinical outcomes and functional signatures in human cancer.多组学整合甲基转移酶样蛋白家族揭示了人类癌症的临床结局和功能特征。
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METTL13 inhibits progression of clear cell renal cell carcinoma with repression on PI3K/AKT/mTOR/HIF-1α pathway and c-Myc expression.METTL13 通过抑制 PI3K/AKT/mTOR/HIF-1α 通路和 c-Myc 表达抑制透明细胞肾细胞癌的进展。
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