Márquez-Ramírez Cristian Adrián, Olmos-Orizaba Berenice Eridani, García-Berumen Claudia Isabel, Calderón-Cortés Elizabeth, Montoya-Pérez Rocío, Saavedra-Molina Alfredo, Rodríguez-Orozco Alain Raimundo, Cortés-Rojo Christian
Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58030, Mexico.
Facultad de Enfermería, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58000, Mexico.
Life (Basel). 2021 Oct 21;11(11):1122. doi: 10.3390/life11111122.
Hypertension impairs the function of the kidney and its vasculature. Adrenergic activation is involved in these processes by promoting oxidative stress and mitochondrial dysfunction. Thus, the targeting of mitochondrial function and mitochondrial oxidative stress may be an approach to alleviate hypertensive kidney damage. Avocado oil, a source of oleic acid and antioxidants, improves mitochondrial dysfunction, decreases mitochondrial oxidative stress, and enhances vascular function in hypertensive rats. However, whether avocado oil improves the function of renal vasculature during the adrenergic stimulation, and if this is related to improvement in renal damage and enhancement of mitochondrial activity is unknown. Thus, the effects of avocado oil on renal vascular responses to adrenergic stimulation, mitochondrial dysfunction, oxidative stress, and renal damage were compared with prazosin, an antagonist of α-adrenoceptors, in hypertensive rats induced by L-NAME. Avocado oil or prazosin decreased blood pressure, improved endothelium-dependent renal vasodilation, prevented mitochondrial dysfunction and kidney damage in hypertensive rats. However, avocado oil, but not prazosin, decreased mitochondrial ROS generation and improved the redox state of mitochondrial glutathione. These results suggest that avocado oil and prazosin prevented hypertensive renal damage due to the improvement in mitochondrial function.
高血压会损害肾脏及其血管系统的功能。肾上腺素能激活通过促进氧化应激和线粒体功能障碍参与这些过程。因此，针对线粒体功能和线粒体氧化应激可能是减轻高血压肾损伤的一种方法。鳄梨油富含油酸和抗氧化剂，可改善线粒体功能障碍，降低线粒体氧化应激，并增强高血压大鼠的血管功能。然而，鳄梨油在肾上腺素能刺激过程中是否能改善肾血管系统的功能，以及这是否与肾损伤的改善和线粒体活性的增强有关尚不清楚。因此，在L-NAME诱导的高血压大鼠中，将鳄梨油对肾血管对肾上腺素能刺激的反应、线粒体功能障碍、氧化应激和肾损伤的影响与α-肾上腺素能受体拮抗剂哌唑嗪进行了比较。鳄梨油或哌唑嗪可降低血压，改善内皮依赖性肾血管舒张，预防高血压大鼠的线粒体功能障碍和肾损伤。然而，鳄梨油而非哌唑嗪可减少线粒体ROS生成并改善线粒体谷胱甘肽的氧化还原状态。这些结果表明，鳄梨油和哌唑嗪通过改善线粒体功能预防了高血压肾损伤。
