Salabura Agata, Łuniewski Aleksander, Kucharska Maria, Myszak Denis, Dołęgowska Barbara, Ciechanowski Kazimierz, Kędzierska-Kapuza Karolina, Wojciuk Bartosz
Clinic of Nephrology, Internal Medicine and Transplantation, Pomeranian Medical University in Szczecin, 70-123 Szczecin, Poland.
Department of Immunological Diagnostics, Pomeranian Medical University in Szczecin, 70-123 Szczecin, Poland.
Life (Basel). 2021 Nov 19;11(11):1264. doi: 10.3390/life11111264.
Virome-a part of a microbiome-is a term used to describe all viruses found in the specific organism or system. Recently, as new technologies emerged, it has been confirmed that kidneys and the lower urinary tract are colonized not only by the previously described viruses, but also completely novel species. Viruses can be both pathogenic and protective, as they often carry important virulence factors, while at the same time represent anti-inflammatory functions. This paper aims to show and compare the viral species detected in various, specific clinical conditions. Because of the unique characteristics of viruses, new sequencing techniques and databases had to be developed to conduct research on the urinary virome. The dynamic development of research on the human microbiome suggests that the detailed studies on the urinary system virome will provide answers to many questions about the risk factors for civilization, cancer, and autoimmune diseases.
病毒组作为微生物组的一部分，是一个用于描述在特定生物体或系统中发现的所有病毒的术语。最近，随着新技术的出现，已证实肾脏和下尿路不仅被先前描述的病毒所定植，而且还存在全新的病毒种类。病毒既可以是致病的，也可以是具有保护作用的，因为它们通常携带重要的毒力因子，同时还具有抗炎功能。本文旨在展示和比较在各种特定临床情况下检测到的病毒种类。由于病毒具有独特的特性，因此必须开发新的测序技术和数据库来开展关于尿液病毒组的研究。人类微生物组研究的蓬勃发展表明，对泌尿系统病毒组的详细研究将为许多有关文明病、癌症和自身免疫性疾病的危险因素的问题提供答案。
