Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstrasse 2, 86156 Augsburg, Germany.
Medicina (Kaunas). 2021 Oct 21;57(11):1141. doi: 10.3390/medicina57111141.
Both clinical-pathological and experimental studies have shown that chemokines play a key role in activating the immune checkpoint modulator in cervical cancer progression and are associated with prognosis in tumor cell proliferation, invasion, angiogenesis, chemoresistance, and immunosuppression. Therefore, a clear understanding of chemokines and immune checkpoint modulators is essential for the treatment of this disease. This review discusses the origins and categories of chemokines and the mechanisms that are responsible for activating immune checkpoints in cervical dysplasia and cancer, chemokines as biomarkers, and therapy development that targets immune checkpoints in cervical cancer research.
临床病理和实验研究均表明，趋化因子在激活宫颈癌进展中的免疫检查点调节剂方面发挥着关键作用，并与肿瘤细胞增殖、浸润、血管生成、化疗耐药和免疫抑制相关。因此，明确趋化因子和免疫检查点调节剂对于治疗这种疾病至关重要。本综述讨论了趋化因子的起源和分类，以及其在宫颈发育不良和癌症中激活免疫检查点的机制，探讨了趋化因子作为生物标志物的作用，以及针对宫颈癌研究中免疫检查点的治疗开发。
