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伴有重症肌无力的妊娠的胎儿监测。

Fetal Surveillance in Pregnancies with Myasthenia Gravis.

机构信息

Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Filantropia Clinical Hospital, 011132 Bucharest, Romania.

出版信息

Medicina (Kaunas). 2021 Nov 20;57(11):1277. doi: 10.3390/medicina57111277.

Abstract

Myasthenia gravis (MG) is an autoimmune condition, that commonly impacts adult women of reproductive age. Myasthenia gravis in pregnancy is rare, but the incidence is higher in different geographical areas. Pregnancies in mothers with MG can have an unfortunate outcome. Acetylcholine receptor antibodies may pass into the fetal circulation and can affect the fetal neuromuscular junction, generating transient MG or even fetal arthrogryposis. The 2016 and 2021 International Consensus Guidance for Management of Myasthenia Gravis issued by Myasthenia Gravis Foundation of America is lacking in recommendation for fetal surveillance for pregnancies in women with MG. The aim of this paper is to highlight fetal and neonatal complications in mothers with MG and to offer antenatal care insights. Close maternal and pregnancy monitoring can improve pregnancy outcome. Patients with MG should be encouraged to conceive, to avoid triggers for exacerbations of the disease during pregnancy and a multidisciplinary team should be established to ensure the optimal support and therapy.

摘要

重症肌无力(MG)是一种自身免疫性疾病,通常影响育龄期成年女性。妊娠合并重症肌无力较为罕见,但在不同地理区域的发病率较高。患有 MG 的母亲的妊娠可能会有不幸的结果。乙酰胆碱受体抗体可能会进入胎儿循环,并影响胎儿的神经肌肉接头,导致短暂性 MG 甚至胎儿手足搐搦症。2016 年和 2021 年美国重症肌无力基金会发布的《重症肌无力管理国际共识指南》缺乏对 MG 孕妇胎儿监测的推荐。本文旨在强调患有 MG 的母亲的胎儿和新生儿并发症,并提供产前护理的见解。密切的母婴监测可以改善妊娠结局。应鼓励患有 MG 的患者怀孕,避免妊娠期间疾病恶化的诱因,并建立多学科团队,以确保获得最佳的支持和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c230/8624595/6f2f440b746d/medicina-57-01277-g001.jpg

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