Hamel Johanna, Ciafaloni Emma
Department of Neurology, Neuromuscular Division, University of Rochester Medical Center, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA.
University of Rochester Medical Center, University of Rochester, 601 Elmwood Avenue, PO Box 673, Rochester, NY 14642, USA.
Neurol Clin. 2018 May;36(2):355-365. doi: 10.1016/j.ncl.2018.01.005.
Myasthenia gravis presents a risk factor for pregnancy and delivery, and can affect the newborn. In return, pregnancy can affect the course of myasthenia and worsen the disease during pregnancy requiring treatment modifications. Treatment optimization and drug safety should be addressed before conception. Delivery is complicated by prolonged labor. Newborns can develop neonatal myasthenia gravis, a treatable and transient disease. Patients should not be discouraged to become pregnant, but provided with supportive counseling, planning, and monitoring in a multidisciplinary team involving obstetrician, anesthesiologist, pediatrician, and neurologist. Pregnancy outcome is favorable in women who receive treatment and expert care.
重症肌无力是妊娠和分娩的一个风险因素，且可能影响新生儿。反过来，妊娠也会影响重症肌无力的病程，并在孕期使病情恶化，需要调整治疗方案。在受孕前应解决治疗优化和药物安全性问题。分娩会因产程延长而变得复杂。新生儿可能会患上新生儿重症肌无力，这是一种可治疗的短暂性疾病。不应劝阻患者怀孕，但应在由产科医生、麻醉师、儿科医生和神经科医生组成的多学科团队中，为其提供支持性咨询、规划和监测。接受治疗和专家护理的女性妊娠结局良好。
