从 sp. Cl 58-27 中分离得到新的肯达霉素衍生物。
New Kendomycin Derivative Isolated from sp. Cl 58-27.
机构信息
Department of Pharmaceutical Biotechnology, Saarland University, 66123 Saarbrücken, Germany.
Department of Genetics and Biotechnology, Ivan Franko University of Lviv, 79005 Lviv, Ukraine.
出版信息
Molecules. 2021 Nov 12;26(22):6834. doi: 10.3390/molecules26226834.
In the course of screening new streptomycete strains, the strain sp. Cl 58-27 caught our attention due to its interesting secondary metabolite production profile. Here, we report the isolation and characterization of an ansamycin natural product that belongs structurally to the already known kendomycins. The structure of the new kendomycin E was elucidated using NMR spectroscopy, and the corresponding biosynthetic gene cluster was identified by sequencing the genome of sp. Cl 58-27 and conducting a detailed analysis of secondary metabolism gene clusters using bioinformatic tools.
在筛选新型链霉菌株的过程中，菌株 sp. Cl 58-27 因其有趣的次生代谢产物产生谱引起了我们的注意。在这里，我们报告了一种 ansamycin 天然产物的分离和表征，该产物在结构上属于已知的 kendomycins。使用 NMR 光谱法阐明了新的 kendomycin E 的结构，并通过测序 sp. Cl 58-27 的基因组以及使用生物信息学工具对次生代谢基因簇进行详细分析，确定了相应的生物合成基因簇。
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