Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL 33458, United States.
Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL 33458, United States; Natural Products Discovery Center, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL 33458, United States; Department of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL 33458, United States; Skaggs Graduate School of Chemical and Biological Sciences, Scripps Research, Jupiter, FL 33458, United States.
Curr Opin Chem Biol. 2023 Oct;76:102366. doi: 10.1016/j.cbpa.2023.102366. Epub 2023 Jul 12.
Sulfur-containing natural products (S-containing NPs) exhibit diverse chemical structures and biosynthetic machineries. Unraveling the intricate chemistry of S-incorporation requires innovative and multidisciplinary approaches. In this review, we surveyed the landscape of S-containing NP biosynthetic machineries, classified the S-incorporation chemistry into four distinct classes, and highlighted each of the four classes with representative examples from recent studies. All highlighted chemistry has been correlated to the genes encoding the biosynthetic machineries of the S-containing NPs, which open new opportunities to discover S-containing NPs through genome mining. These examples should inspire the community to explore uncharted territories in NP research, promoting further advancements in both novel S-containing NP discovery and S-incorporation chemistry.
含硫天然产物（S-containing NPs）具有多样的化学结构和生物合成机制。揭示 S 掺入的复杂化学需要创新和多学科的方法。在这篇综述中，我们调查了含硫 NP 生物合成机制的全景，将 S 掺入化学分为四个不同的类别，并以最近研究中的代表性例子突出了每个类别。所有突出的化学都与编码含硫 NP 生物合成机制的基因相关联，这为通过基因组挖掘发现含硫 NP 提供了新的机会。这些例子应该激励科学界探索 NP 研究的未知领域，促进新型含硫 NP 发现和 S 掺入化学的进一步发展。
