Institute of Clinical Pharmacology and Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China; Department of Pharmacy, Shenzhen Shekou People's Hospital, Shenzhen, China.
Institute of Clinical Pharmacology and Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Eur J Pharmacol. 2018 Jan 5;818:96-102. doi: 10.1016/j.ejphar.2017.10.044. Epub 2017 Oct 21.
Liver regeneration is a vital process of recovery after liver damage, which is a promising clinical strategy after partial hepatectomy (PHx). Schisandrol B (SolB), one of the bioactive ingredients from Schisandra sphenanthera, displays significant hepato-protection effects against drug-induced liver injure in mice. However, the effect of SolB on liver regeneration after PHx remains unclear. Here, we showed that SolB treatment promoted liver mass restoration and increased the number of proliferative hepatocytes following PHx. SolB treatment significantly improved the levels of growth factors (HGF and EGF) and cytokines (IL-6), which further activated STAT3/Akt/MAPK signaling pathways and induced the expression of several the protein of cell cycle core. Overall, this study is the first to demonstrate the role of SolB in promoting liver regeneration during PHx challenge, which provide a clinically relevant argument for using SolB to facilitate liver recovery after undergoing PHx or liver transplantation.
肝再生是肝脏损伤后的恢复过程，是部分肝切除术（PHx）后的一种有前途的临床策略。五味子醇 B（SolB）是五味子中的一种生物活性成分，对小鼠药物性肝损伤具有显著的肝保护作用。然而，SolB 对 PHx 后肝再生的影响尚不清楚。在这里，我们表明 SolB 治疗可促进 PHx 后肝质量的恢复，并增加增殖性肝细胞的数量。SolB 治疗可显著提高生长因子（HGF 和 EGF）和细胞因子（IL-6）的水平，进一步激活 STAT3/Akt/MAPK 信号通路，并诱导细胞周期核心蛋白的表达。总的来说，这项研究首次证明了 SolB 在促进 PHx 期间肝再生中的作用，为使用 SolB 促进 PHx 或肝移植后肝恢复提供了临床相关的依据。
