South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, Institute of Aquaculture and Protection of Waters, University of South Bohemia in České Budějovice, Na Sádkách 1780, 37005 České Budějovice, Czech Republic.
Institute of Entomology, Biology Centre, Czech Academy of Science, 37005 České Budějovice, Czech Republic.
Molecules. 2021 Nov 21;26(22):7036. doi: 10.3390/molecules26227036.
Plants consistently synthesize and accumulate medically valuable secondary metabolites which can be isolated and clinically tested under in vitro conditions. An advancement with such important phytochemical production has been recognized and utilized as herbal drugs. Bioactive andrographolide (AGL; CHO) isolated from (AP) (Kalmegh) is a diterpenoid lactones having multifunctional medicinal properties including anti-manic, anti-inflammatory, liver, and lung protective. AGL is known for its immunostimulant activity against a variety of microbial infections thereby, regulating classical and alternative macrophage activation, Ag-specific antibody production during immune disorder therapy. In vitro studies with AGL found it to be effective against multiple tumors, neuronal disorders, diabetes, pneumonia, fibrosis, and other diverse therapeutic misadventures. Generally, virus-based diseases like ZIKA, influenza A virus subtype (H1NI), Ebola (EBOV), Dengue (DENV), and coronavirus (COVID-19) epidemics have greatly increased scientific interest and demands to develop more effective and economical immunomodulating drugs with minimal side effects. Trials and in vitro pharmacological studies with AGL and medicinally beneficial herbs might contribute to benefit the human population without using chemical-based synthetic drugs. In this review, we have discussed the possible role of AGL as a promising herbal-chemo remedy during human diseases, viral infections and as an immunity booster.
植物持续合成和积累具有医学价值的次生代谢产物，这些产物可以在体外条件下被分离并进行临床测试。这种重要的植物化学物质生产的进步已被认可并用作草药药物。从 （AP）（Kalmegh）中分离出的具有生物活性的穿心莲内酯（AGL；CHO）是一种二萜内酯，具有多种药用特性，包括抗躁狂、抗炎、保肝和保肺。AGL 以其对多种微生物感染的免疫刺激活性而闻名，从而调节经典和替代巨噬细胞的激活、在免疫紊乱治疗期间产生 Ag 特异性抗体。体外研究发现 AGL 对多种肿瘤、神经紊乱、糖尿病、肺炎、纤维化和其他不同的治疗并发症有效。一般来说，基于病毒的疾病，如 Zika、甲型流感病毒亚型（H1NI）、埃博拉（EBOV）、登革热（DENV）和冠状病毒（COVID-19）流行，极大地增加了开发更有效和经济的免疫调节药物的科学兴趣和需求，这些药物具有最小的副作用。AGL 和药用有益草药的试验和体外药理学研究可能有助于在不使用基于化学的合成药物的情况下使人类受益。在这篇综述中，我们讨论了 AGL 作为一种有前途的草药-化疗药物在人类疾病、病毒感染和作为免疫增强剂中的可能作用。
