Mazur Marcelina, Masłowiec Dorota
Department of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland.
Institute of Health Sciences, University of Opole, Katowicka 68, 45-060 Opole, Poland.
Antibiotics (Basel). 2022 Sep 29;11(10):1327. doi: 10.3390/antibiotics11101327.
The development of bacterial resistance to antibiotics and the consequent lack of effective therapy is one of the biggest problems in modern medicine. A consequence of these processes is an urgent need to continuously design and develop novel antimicrobial agents. Among the compounds showing antimicrobial potential, lactones are a group to explore. For centuries, their antimicrobial activities have been used in folk medicine. Currently, novel lactone compounds are continuously described in the literature. Some of those structures exhibit high antimicrobial potential and some are an inspiration for design and synthesis of future drugs. This paper describes recent developments on antimicrobial lactones with smaller ring sizes, up to seven membered ε-lactones. Their isolation from natural sources, chemical synthesis, synergistic activity with antibiotics, and effects on quorum sensing are presented herein.
细菌对抗生素产生耐药性以及随之而来的有效治疗方法的缺乏是现代医学中最大的问题之一。这些过程的一个后果是迫切需要持续设计和开发新型抗菌剂。在具有抗菌潜力的化合物中，内酯是一类值得探索的物质。几个世纪以来，它们的抗菌活性已被应用于民间医学。目前，文献中不断有新型内酯化合物被报道。其中一些结构具有很高的抗菌潜力，一些则为未来药物的设计与合成提供了灵感。本文描述了环尺寸较小（至多七元ε-内酯）的抗菌内酯的最新进展。文中介绍了它们从天然来源的分离、化学合成、与抗生素的协同活性以及对群体感应的影响。
Zotero 插件
