Lee Chen-Hung, Liu Kuo-Sheng, Roth Julien George, Hung Kuo-Chun, Liu Yen-Wei, Wang Shin-Huei, Kuo Chi-Ching, Liu Shih-Jung
Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Chang Gung University College of Medicine, Taoyuan 33305, Taiwan.
Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.
Pharmaceutics. 2021 Oct 21;13(11):1756. doi: 10.3390/pharmaceutics13111756.
Stent implantation impairs local endothelial function and may be associated with subsequent adverse cardiovascular events. Telmisartan, an angiotensin II receptor blocker that has unique peroxisome proliferator-activated-receptor-gamma-mediated effects on cardiovascular disease, has been shown to enhance endothelial function and limit neointimal hyperplasia. This study utilized hybrid biodegradable/stent nanofibers to facilitate sustained and local delivery of telmisartan to injured arterial vessels. Telmisartan and poly(d,l)-lactide--glycolide (PLGA) (75:25) were dissolved in hexafluoroisopropyl alcohol and electrospun into biodegradable nanofibrous tubes which were coated onto metal stents. By releasing 20% of the loaded telmisartan in 30 days, these hybrid biodegradable/stent telmisartan-loaded nanofibers increased the migration of endothelial progenitor cells in vitro, promoted endothelialization, and reduced intimal hyperplasia. As such, this work provides insights into the use of PLGA nanofibers for treating patients with an increased risk of stent restenosis.
支架植入会损害局部内皮功能，并可能与随后的不良心血管事件相关。替米沙坦是一种血管紧张素II受体阻滞剂，对心血管疾病具有独特的过氧化物酶体增殖物激活受体γ介导的作用，已被证明可增强内皮功能并限制内膜增生。本研究利用可生物降解/支架混合纳米纤维促进替米沙坦向受损动脉血管的持续局部递送。将替米沙坦和聚（d，l）-丙交酯-乙交酯（PLGA）（75:25）溶解在六氟异丙醇中，然后静电纺丝成可生物降解的纳米纤维管，将其涂覆在金属支架上。通过在30天内释放20%负载的替米沙坦，这些可生物降解/支架混合负载替米沙坦的纳米纤维在体外增加了内皮祖细胞的迁移，促进了内皮化，并减少了内膜增生。因此，这项工作为使用PLGA纳米纤维治疗支架再狭窄风险增加的患者提供了见解。
