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静电纺丝在药物传递应用中的研究进展:综述。

Electrospinning for drug delivery applications: A review.

机构信息

Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza, 2, 20126 Milan, Italy.

Complex Tissue Regeneration Department, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Universiteitssingel 40, 6229 ET Maastricht, the Netherlands.

出版信息

J Control Release. 2021 Jun 10;334:463-484. doi: 10.1016/j.jconrel.2021.03.033. Epub 2021 Mar 26.

Abstract

Drug delivery devices are promising tools in the pharmaceutical field, as they are able to maximize the therapeutic effects of the delivered drug while minimizing the undesired side effects. In the past years, electrospun nanofibers attracted rising attention due to their unique features, like biocompatibility and broad flexibility. Incorporation of active principles in nanofibrous meshes proved to be an efficient method for in situ delivery of a wide range of drugs, expanding the possibility and applicability of those devices. In this review, the principle of electrospinning and different fields of applications are treated to give an overview of the recent literature, underlining the easy tuning and endless combination of this technique, that in the future could be the new frontier of personalized medicine.

摘要

给药装置是制药领域很有前景的工具,因为它们能够最大限度地提高所输送药物的治疗效果,同时使不希望出现的副作用最小化。在过去的几年中,由于具有生物相容性和广泛的灵活性等独特特性,电纺纳米纤维引起了越来越多的关注。将活性原理纳入纳米纤维网中被证明是原位输送各种药物的有效方法,扩大了这些装置的可能性和适用性。在这篇综述中,处理了静电纺丝的原理和不同的应用领域,以概述最近的文献,强调了该技术的易于调节和无尽组合,这在未来可能成为个性化医疗的新前沿。

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