Infectious Disease Department, Nord Franche-Comté Hospital, 90400 Trevenans, France.
Clinical Investigation Center, Jean Minjoz University Hospital of Besançon, 25000 Besancon, France.
Viruses. 2021 Oct 25;13(11):2151. doi: 10.3390/v13112151.
Many studies have investigated post-COVID symptoms, but the predictors of symptom persistence remain unknown. The objective was to describe the natural course of the disease at 6 months and to identify possible factors favoring the resurgence or persistence of these symptoms. COVEVOL is a retrospective observational descriptive study of 74 patients. All patients with positive SARS-CoV-2 PCR from March 2020 were included. We compared a group with symptom persistence (PS group) with another group without symptom persistence (no-PS group). Fifty-three out of seventy-four patients (71.62%) described at least one persistent symptom at 6 months of SARS-CoV-2 infection. In the PS group, 56.6% were women and the average age was 54.7 years old [21-89.2] ± 16.9. The main symptoms were asthenia (56.6%, = 30), dyspnea (34%, = 18), anxiety (32.1% = 17), anosmia (24.5%, = 13) and agueusia (15.1% = 8). Ten patients (13.51%) presented a resurgence in symptoms. Patients in the PS group were older ( = 0.0048), had a higher BMI ( = 0.0071), and were more frequently hospitalized ( = 0.0359) compared to the no-PS group. Odynophagia and nasal obstruction were less present in the inaugural symptoms of COVID-19 in the PS group ( = 0.0202 and = 0.0332). Persistent post-COVID syndromes are common and identification of contributing factors is necessary for understanding this phenomenon and appropriate management.
许多研究都调查了新冠后症状，但症状持续存在的预测因素仍不清楚。目的是描述疾病在 6 个月时的自然病程，并确定可能有利于这些症状复发或持续存在的因素。COVEVOL 是一项回顾性观察描述性研究，纳入了 74 名患者。所有 2020 年 3 月 SARS-CoV-2 PCR 阳性的患者均被纳入研究。我们比较了有症状持续存在（PS 组）和无症状持续存在（无 PS 组）的两组患者。74 例患者中有 53 例（71.62%）在 SARS-CoV-2 感染后 6 个月至少描述了一种持续症状。PS 组中，56.6%为女性，平均年龄为 54.7 岁[21-89.2]±16.9。主要症状为乏力（56.6%， = 30）、呼吸困难（34%， = 18）、焦虑（32.1%， = 17）、嗅觉丧失（24.5%， = 13）和味觉丧失（15.1%， = 8）。10 例（13.51%）患者出现症状复发。PS 组患者年龄较大（ = 0.0048）、BMI 较高（ = 0.0071）、住院治疗更频繁（ = 0.0359），与无 PS 组相比。PS 组首发 COVID-19 症状中咽痛和鼻塞较少见（ = 0.0202 和 = 0.0332）。新冠后持续性综合征较为常见，确定其促成因素对于理解这一现象和进行适当的管理是必要的。
