Zahid Muhammad Nauman
Department of Biology, College of Science, University of Bahrain, Sakhir 32038, Bahrain.
Vaccines (Basel). 2021 Nov 22;9(11):1369. doi: 10.3390/vaccines9111369.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) created a global pandemic (COVID-19) that has resulted in massive health and economic losses. The current unavailability of treatments leaves vaccination as the only way to control this disease. There are four vaccines (Sinopharm, Pfizer-BioNTech, Sputnik, and AstraZeneca) available in Bahrain. This project aimed to study the most common side effects resulting from the first and second doses of these four vaccines. Data were collected through an online questionnaire answered by 311 individuals who received both doses of one of these four vaccines. The results of this study revealed that regardless of the vaccine identity, participants experienced more side effects from the second dose. Among the different side effects, pain at the site of injection was primarily observed after the first dose of the Pfizer vaccine (43%), which was followed by the AstraZeneca vaccine (31%). Moreover, fever was observed in participants after the first dose of the Sputnik vaccine (37%), while headache was mainly observed after the first dose of the Pfizer vaccine (32%). It is important to note that fatigue was observed after the first dose of all four vaccines but was reported by the highest proportion of respondents in the Pfizer group (28%). Interestingly, there are some side effects, such as pain at the site of injection, that are correlated with fever ( = 0.909). Similarly, headache is correlated with fever ( = 0.801) and pain at the site of injection ( = 0.868). Overall, it was observed that recipients of the Sinopharm vaccine reported the mildest side effects among all four vaccines. The crucial finding of this study is that the first and second dosage post-vaccination side effects were modest and predictable with no occurrences of hospitalization; this information can assist in lessening vaccine apprehension.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发了全球大流行（COVID-19），造成了巨大的健康和经济损失。目前尚无治疗方法，接种疫苗是控制这种疾病的唯一途径。巴林有四种疫苗（国药集团、辉瑞-生物新技术公司、卫星V和阿斯利康）可供使用。本项目旨在研究这四种疫苗第一剂和第二剂接种后最常见的副作用。通过在线问卷收集数据，311名接种了这四种疫苗之一两剂的个人回答了问卷。本研究结果显示，无论疫苗种类如何，参与者在接种第二剂后出现的副作用更多。在不同的副作用中，接种辉瑞疫苗第一剂后主要观察到注射部位疼痛（43%），其次是阿斯利康疫苗（31%）。此外，接种卫星V疫苗第一剂后，参与者出现发热（37%），而接种辉瑞疫苗第一剂后主要观察到头痛（32%）。需要注意的是，接种所有四种疫苗第一剂后均观察到疲劳，但辉瑞组报告疲劳的受访者比例最高（28%）。有趣的是，有些副作用，如注射部位疼痛，与发热相关（=0.909）。同样，头痛与发热相关（=0.801），也与注射部位疼痛相关（=0.868）。总体而言，观察到国药集团疫苗接种者报告的副作用在所有四种疫苗中最为轻微。本研究的关键发现是，接种疫苗后的第一剂和第二剂副作用较小且可预测，没有出现住院情况；这些信息有助于减轻对疫苗的担忧。
