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国药新冠疫苗在接种的医学生和医护人员中的不良反应

Adverse Effects of Sinopharm COVID-19 Vaccine among Vaccinated Medical Students and Health Care Workers.

作者信息

Meo Anusha Sultan, Masood Adeeba, Shabbir Usama, Ali Hubba, Nadeem Zeeshan, Meo Sultan Ayoub, Alshahrani Abdullah Nasser, AlAnazi Saad, Al-Masri Abeer A, Al-Khlaiwi Thamir

机构信息

College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.

Army Medical College, National University of Medical Sciences, Rawalpindi 46000, Pakistan.

出版信息

Vaccines (Basel). 2023 Jan 1;11(1):105. doi: 10.3390/vaccines11010105.

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease caused a highly problematic situation worldwide. Various vaccines were launched to combat the COVID-19 pandemic. This study aims to investigate the adverse effects of first and second doses of the Sinopharm vaccine among vaccinated medical and dental students and healthcare workers. A well-established questionnaire was distributed online, and 414 medical and dental students and healthcare workers (HCW) comprising 355 females (85.7%) and 59 males (14.3%) participated; all were vaccinated with two doses of Sinopharm. The most common side effect was pain at the injection site after dose one in 253 respondents (61.3%) and after dose two in 161 respondents (38.9%). Other symptoms included general lethargy in 168 (40.6%), myalgia/body pain in 99 (23.9%), low-grade fever in 93 (22.4%), and headache in 87 (21%) respondents. Common side effects reported after the second dose of the vaccine following pain at the injection site included general lethargy in 21.3% (88), headache in 10.4% (43), myalgia/body pain in 9.9% (41), and low-grade fever in 6.1% (25) of the respondents. In conclusion, common adverse effects of the Sinopharm vaccine were pain at the injection site, general lethargy, myalgia, body pain, low-grade fever, and headache. These adverse effects were mild in intensity for both doses but slightly more frequent and severe for the first dose than the second dose.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)疾病在全球范围内造成了极为棘手的局面。为抗击新冠疫情,多种疫苗相继问世。本研究旨在调查接种国药疫苗的医科和牙科学生以及医护人员在接种第一剂和第二剂疫苗后的不良反应。通过在线发放一份成熟的调查问卷,共有414名医科和牙科学生以及医护人员参与,其中包括355名女性(85.7%)和59名男性(14.3%);所有人均接种了两剂国药疫苗。最常见的副作用是,253名受访者(61.3%)在接种第一剂后出现注射部位疼痛,161名受访者(38.9%)在接种第二剂后出现注射部位疼痛。其他症状包括168人(40.6%)出现全身乏力、99人(23.9%)出现肌痛/身体疼痛、93人(22.4%)出现低热以及87人(21%)出现头痛。在接种第二剂疫苗后,继注射部位疼痛之后报告的常见副作用包括,21.3%(88人)出现全身乏力、10.4%(43人)出现头痛、9.9%(41人)出现肌痛/身体疼痛以及6.1%(25人)出现低热。总之,国药疫苗的常见不良反应为注射部位疼痛、全身乏力、肌痛、身体疼痛、低热和头痛。两剂疫苗的这些不良反应强度均较轻,但第一剂比第二剂出现得稍频繁且严重程度稍高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c96b/9863525/f5b2d262619e/vaccines-11-00105-g001.jpg

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