Emergency Department, Department of Emergency and Critical Medicine, Wan Fang Hospital, Taipei Medical University, Taipei City 11696, Taiwan.
Department of Emergency, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 11031, Taiwan.
Nutrients. 2021 Oct 20;13(11):3684. doi: 10.3390/nu13113684.
Mounting evidence demonstrates that a high-salt diet (HSD) not only affects hemodynamic changes but also disrupts immune homeostasis. The T helper 17 (Th17) and regulatory T cells (Tregs) are susceptible to hypersalinity. However, research on the influence of sodium on Th2-mediated food allergies remains scarce. We aimed to investigate the effect of dietary sodium on the immune response to food allergies. Mice maintained on an HSD (4% NaCl), low-salt diet (LSD; 0.4% NaCl), or control diet (CTRL; 1.0% NaCl) were orally sensitized with ovalbumin (OVA) and a cholera toxin (CT) adjuvant, and then subjected to an intragastric OVA challenge. OVA-specific immunoglobulin G (IgG), IgG1, IgG2a, and IgE antibodies were significantly higher in the HSD group than in the CTRL group ( 0.001, < 0.05, < 0.01, and < 0.05, respectively). Mice on HSD had significantly higher interleukin (IL)-4 levels than the CTRL group ( < 0.01). The IL-10 levels were significantly lower in the HSD group than in the CTRL group ( < 0.05). The serum levels of interferon-γ (IFN-γ), sodium, and chloride did not differ among the three groups. This study indicates that excessive salt intake promotes Th2 responses in a mouse model of food allergy.
越来越多的证据表明，高盐饮食（HSD）不仅会影响血液动力学变化，还会破坏免疫稳态。辅助性 T 细胞 17（Th17）和调节性 T 细胞（Tregs）对高盐敏感。然而，关于钠对 Th2 介导的食物过敏影响的研究仍然很少。我们旨在研究饮食钠对食物过敏免疫反应的影响。将维持在高盐饮食（HSD；4% NaCl）、低盐饮食（LSD；0.4% NaCl）或对照饮食（CTRL；1.0% NaCl）的小鼠用卵清蛋白（OVA）和霍乱毒素（CT）佐剂进行口服致敏，然后进行胃内 OVA 挑战。OVA 特异性免疫球蛋白 G（IgG）、IgG1、IgG2a 和 IgE 抗体在 HSD 组中明显高于 CTRL 组（分别为<0.001、<0.05、<0.01 和<0.05）。HSD 组的白细胞介素（IL）-4 水平明显高于 CTRL 组（<0.01）。HSD 组的 IL-10 水平明显低于 CTRL 组（<0.05）。三组间血清干扰素-γ（IFN-γ）、钠和氯水平无差异。这项研究表明，在食物过敏的小鼠模型中，过量的盐摄入会促进 Th2 反应。
