Department of Neurology, Korea University Anam Hospital, Korea University Medicine, Seoul 02841, Korea.
Rodem Hospital, Incheon 22142, Korea.
Nutrients. 2021 Oct 21;13(11):3704. doi: 10.3390/nu13113704.
Adequate nutritional support and high body mass index (BMI) are good prognostic factors for disease progression and survival in amyotrophic lateral sclerosis (ALS). However, whether the composition of body weight, such as body fat percentage, has an independent effect on ALS prognosis remains unclear. The clinical data of 53 ALS patients were collected by medical record review. The data included: disease onset, sex, age, time of diagnosis, survival duration, presence of percutaneous endoscopic gastrostomy (PEG), nasogastric tube, tracheostomy, and availability of oral intake throughout the course of the disease, and interval measurement values of body mass by bioelectrical impedance analysis (BIA). The interval change (∆) of the BIA parameters was calculated by subtracting the follow-up values from the baseline values. Change in body fat percentage/interval between BIA measurements (months) (hazard ratio [HR] = 0.374, = 0.0247), and availability of oral food intake (HR = 0.167, = 0.02), were statistically significant for survival duration in multivariate hazard proportional regression analysis. Survival analysis and Kaplan-Meier curves showed similar results. Higher average monthly change in body fat percentage and availability of oral food intake are prognostic factors in ALS survival.
足够的营养支持和较高的体重指数（BMI）是肌萎缩侧索硬化症（ALS）疾病进展和生存的良好预后因素。然而，体重的组成部分，如体脂百分比，是否对 ALS 预后有独立影响尚不清楚。通过病历回顾收集了 53 名 ALS 患者的临床数据。数据包括：发病时间、性别、年龄、诊断时间、生存时间、经皮内镜下胃造口术（PEG）、鼻胃管、气管切开术以及疾病过程中是否可经口摄入的情况，以及通过生物电阻抗分析（BIA）测量的体重的间隔测量值。通过从基线值中减去随访值来计算 BIA 参数的间隔变化（∆）。在多变量风险比例回归分析中，BIA 测量值之间的体脂百分比变化/间隔（月）（风险比 [HR] = 0.374， = 0.0247）和口服食物摄入的可用性（HR = 0.167， = 0.02）对生存时间有统计学意义。生存分析和 Kaplan-Meier 曲线显示了相似的结果。体脂百分比和口服食物摄入的平均每月变化较高是 ALS 生存的预后因素。
