School of Health Sciences, Örebro University, 701 82 Örebro, Sweden.
Service of Obstetrics and Gynecology, Hospital Clínico Universitario-INCLIVA, 46010 Valencia, Spain.
Nutrients. 2021 Oct 24;13(11):3753. doi: 10.3390/nu13113753.
To what extent the intake of fruit and vegetables (FV) influences inflammatory status remains elusive, particularly in older populations. The aim of the present study was to determine the effect of increased FV intake for 16 weeks on circulating biomarkers of inflammation in a population of older men and women. Sixty-six participants (65-70 years) randomly assigned to either FV or control (CON) groups were instructed to increase FV intake to five servings per day through nutritional counseling (FV) or to maintain habitual diet (CON). Dietary intake and physical activity level (PA) were determined using food frequency questionnaire and accelerometers, respectively, at the start and end of the intervention. C-reactive protein (CRP), interleukin 6 (IL-6), IL-18, macrophage inflammatory protein-1α (MIP-1α), MIP-1β, tumor necrosis factor-α (TNF-α), TNF-related apoptosis-inducing ligand (TRAIL), TNF-related activation-induced cytokine (TRANCE), and C-X3-C motif chemokine ligand-1 (CX3CL1, or fractalkine) were analyzed. The FV group significantly increased daily FV intake (from 2.2 ± 1.3 to 4.2 ± 1.8 servings/day), with no change in CON. Waist circumference and PA level were unchanged by the intervention. Interaction effects (time × group, < 0.05) for TRAIL, TRANCE, and CX3CL1 denoting a significant decrease ( < 0.05) in FV but not in CON were observed. No corresponding effects on CRP, IL6, TNF-α, MIP-1α, and β and IL-18 were observed. The present study demonstrates the influence of increased FV consumption on levels of some inflammatory biomarkers in a population of older adults. Future work is warranted to examine the clinical implications of FV-induced alterations in these inflammatory biomarkers.
摄入水果和蔬菜（FV）在多大程度上影响炎症状态仍不清楚，尤其是在老年人群中。本研究的目的是确定在老年男性和女性人群中，16 周增加 FV 摄入量对循环炎症生物标志物的影响。66 名参与者（65-70 岁）随机分为 FV 组或对照组（CON），通过营养咨询（FV）指导 FV 摄入量增加到每天 5 份，或维持习惯性饮食（CON）。在干预开始和结束时，分别使用食物频率问卷和加速度计来确定膳食摄入量和身体活动水平（PA）。分析了 C 反应蛋白（CRP）、白细胞介素 6（IL-6）、IL-18、巨噬细胞炎症蛋白 1α（MIP-1α）、MIP-1β、肿瘤坏死因子-α（TNF-α）、肿瘤坏死因子相关凋亡诱导配体（TRAIL）、TNF 相关激活诱导细胞因子（TRANCE）和 C-X3-C 基序趋化因子配体 1（CX3CL1，或 fractalkine）。FV 组的每日 FV 摄入量显著增加（从 2.2±1.3 份增加到 4.2±1.8 份/天），而 CON 组没有变化。干预对腰围和 PA 水平没有影响。TRAIL、TRANCE 和 CX3CL1 的交互作用（时间×组，<0.05）表明 FV 组显著下降（<0.05），而 CON 组没有变化。CRP、IL6、TNF-α、MIP-1α 和β以及 IL-18 没有观察到相应的变化。本研究表明，在老年人群中，增加 FV 消耗对一些炎症生物标志物水平有影响。未来需要进一步研究 FV 对这些炎症生物标志物的改变的临床意义。
