St. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland.
Faculty of Medicine, University of Basel, 4001 Basel, Switzerland.
Nutrients. 2021 Nov 5;13(11):3950. doi: 10.3390/nu13113950.
In patients with obesity, accelerated nutrients absorption is observed. Xylitol and erythritol are of interest as alternative sweeteners, and it has been shown in rodent models that their acute ingestion reduces intestinal glucose absorption. This study aims to investigate whether a chronic intake of xylitol and erythritol impacts glucose absorption in humans with obesity. Forty-six participants were randomized to take either 8 g of xylitol or 12 g of erythritol three times a day for five to seven weeks, or to be part of the control group (no substance). Before and after the intervention, intestinal glucose absorption was assessed during an oral glucose tolerance test with 3--methyl-glucose (3-OMG). The effect of xylitol or erythritol intake on the area under the curve for 3-OMG concentration was not significant. Neither the time (pre or post intervention), nor the group (control, xylitol, or erythritol), nor the time-by-group interaction effects were significant ( 0.829, 0.821, and 0.572, respectively). Therefore, our results show that a chronic intake of the natural sweeteners xylitol and erythritol does not affect intestinal glucose absorption in humans with obesity.
在肥胖患者中，观察到营养物质吸收加速。木糖醇和赤藓糖醇作为替代甜味剂引起了人们的兴趣，啮齿动物模型研究表明，它们的急性摄入可减少肠道葡萄糖吸收。本研究旨在探讨慢性摄入木糖醇和赤藓糖醇是否会影响肥胖人群的葡萄糖吸收。46 名参与者被随机分为三组，每天服用 8 克木糖醇或 12 克赤藓糖醇，每天 3 次，持续 5 至 7 周，或作为对照组（不摄入任何物质）。在干预前后，通过口服 3-甲基葡萄糖（3-OMG）进行口服葡萄糖耐量试验，评估肠道葡萄糖吸收情况。木糖醇或赤藓糖醇摄入对 3-OMG 浓度曲线下面积的影响不显著。时间（干预前或干预后）、组（对照组、木糖醇组或赤藓糖醇组）和时间-组交互作用均无显著影响（分别为 0.829、0.821 和 0.572）。因此，我们的研究结果表明，肥胖人群慢性摄入天然甜味剂木糖醇和赤藓糖醇不会影响肠道葡萄糖吸收。
