St. Clara Research Ltd., St. Claraspital, 4002 Basel, Switzerland.
Faculty of Medicine, University of Basel, 4001 Basel, Switzerland.
Int J Mol Sci. 2022 Aug 30;23(17):9867. doi: 10.3390/ijms23179867.
The natural sweeteners erythritol and xylitol might be helpful to reduce sugar consumption and therefore prevent obesity and diabetes. The aim of the present study was to determine the absorption and metabolization into erythronate of different concentrations of erythritol and xylitol. Seventeen healthy lean participants received intragastric solutions of 10, 25, or 50 g erythritol or 7, 17, or 35 g xylitol on three study days in a randomized order. The study was double blinded with respect to the doses administered. We assessed plasma concentrations of erythritol, xylitol, and erythronate at fixed time intervals after administration with gas chromatography-mass spectrometry. We found: (i) a dose-dependent and saturable absorption of erythritol, (ii) a very low absorption of xylitol, (iii) a dose-dependent metabolization of erythritol into erythronate, and (iv) no metabolization of xylitol into erythronate. The implications of the metabolization of erythritol into erythronate for human health remain to be determined and more research in this area is needed.
天然甜味剂赤藓糖醇和木糖醇可能有助于减少糖的摄入，从而预防肥胖和糖尿病。本研究的目的是确定不同浓度的赤藓糖醇和木糖醇被吸收并转化为赤藓酮酸盐的情况。17 名健康的瘦参与者在三天内以随机顺序接受了 10、25 或 50 克赤藓糖醇或 7、17 或 35 克木糖醇的胃内溶液。该研究在给药方面是双盲的。我们使用气相色谱-质谱法在给药后固定时间间隔评估了血浆中赤藓糖醇、木糖醇和赤藓酮酸盐的浓度。我们发现：(i) 赤藓糖醇的吸收呈剂量依赖性和饱和性，(ii) 木糖醇的吸收非常低，(iii) 赤藓糖醇的吸收呈剂量依赖性转化为赤藓酮酸盐，(iv) 木糖醇不会转化为赤藓酮酸盐。赤藓糖醇转化为赤藓酮酸盐对人类健康的影响仍有待确定，需要在这一领域进行更多的研究。
