College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.
Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.
Nutrients. 2021 Nov 8;13(11):3976. doi: 10.3390/nu13113976.
Coffee is widely consumed worldwide and impacts glucose metabolism. After a previous meta-analysis that evaluated the effects of coffee consumption on insulin resistance and sensitivity, additional randomized controlled trials (RCTs) were conducted. This meta-analysis aimed to evaluate the effects of coffee consumption on insulin resistance or sensitivity. We selected RCTs that evaluated the effects of coffee consumption for seven days or more on insulin sensitivity or resistance using surrogate indices (homeostasis model assessment for insulin resistance (HOMA-IR) and Matsuda index). The fixed-effects or random-effects model was used according to heterogeneity. Four studies with 268 participants were analyzed in this meta-analysis. Coffee consumption significantly decreased HOMA-IR compared to control (mean difference (MD) = -0.13; 95% CI = -0.24--0.03; -value = 0.01). However, the significance was not maintained in the sensitivity analysis (MD = -0.04; 95% CI = -0.18-0.10; -value = 0.55) after excluding data from the healthy, young, normal-weight group. Matsuda index was not significantly different between coffee and control groups (standardized mean difference (SMD) = -0.33; 95% CI = -0.70-0.03; -value = 0.08). In conclusion, long-term coffee consumption has a nonsignificant effect on insulin resistance and sensitivity. More studies evaluating the effects of coffee consumption in the healthy, young, and normal-weight individuals are needed.
咖啡在全球范围内广泛饮用，会影响葡萄糖代谢。在之前的一项评估咖啡摄入对胰岛素抵抗和敏感性影响的荟萃分析后，又进行了更多的随机对照试验（RCT）。本次荟萃分析旨在评估咖啡摄入对胰岛素抵抗或敏感性的影响。我们选择了那些评估咖啡摄入对胰岛素敏感性或抵抗的 RCT，这些 RCT 使用替代指标（胰岛素抵抗评估的稳态模型（HOMA-IR）和 Matsuda 指数），且咖啡摄入持续 7 天或以上。根据异质性，采用固定效应或随机效应模型。本荟萃分析共分析了四项研究，共 268 名参与者。与对照组相比，咖啡摄入显著降低了 HOMA-IR（平均差异（MD）=-0.13；95%置信区间（CI）=-0.24 至 -0.03；-值=0.01）。然而，在排除健康、年轻、正常体重组的数据后，敏感性分析（MD=-0.04；95%CI=-0.18 至 0.10；-值=0.55）中，其显著性不再维持。咖啡组和对照组的 Matsuda 指数无显著差异（标准化均数差（SMD）=-0.33；95%CI=-0.70 至 0.03；-值=0.08）。总之，长期咖啡摄入对胰岛素抵抗和敏感性没有显著影响。需要更多研究来评估健康、年轻、正常体重个体中咖啡摄入的影响。
