Department of Endocrinology, the Second Hospital of Jilin University, Changchun, Jilin, China.
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Phytother Res. 2020 Sep;34(9):2159-2169. doi: 10.1002/ptr.6667. Epub 2020 Mar 11.
Studies regarding the influence of green coffee extract (GCE) on blood glucose levels are conflicting. Thus, we sought to conduct a meta-analysis and systematic review of all available randomized controlled trials (RCTs) to quantify the effects of GCE and CGA intervention on blood glucose and insulin levels. We performed systematic online searches in Scopus, Web of science, and PubMed databases, from inception to July 2019. Data were combined analyzed using a random effects model (Der Simonian-Laird method) and reported as weighted mean differences (WMD). Ten trials reported the influences of GCE on FBS and insulin and were subsequently entered into the meta-analysis. Combined results highlighted that FBS was significantly altered after GCE consumption (WMD: -1.791 mg/dl, 95% CI -3.404, -0.177), with no significant heterogeneity among the studies (I = 35.0%, p = .128). However, overall results demonstrated that GCE administration did not result in any significant alteration in insulin levels (WMD: -0.925 μU/ml, 95% CI:-1.915, 0.064), with significant heterogeneity found across studies (I = 87.9%). In sub-group analysis, insulin levels were significantly reduced when GCE was supplemented in dosages of ≥400 mg/day (WMD:-1.942 mg/dl, 95% CI:-1.184, -0.975; I = 0.0%). The results of present study support the use of GCE for the enhancement of blood glucose, while subgroup analysis highlighted significant improvements in insulin levels when GCE is supplemented in doses ≥400 mg/day.
关于绿原酸（GCE）对血糖水平影响的研究结果相互矛盾。因此，我们旨在进行一项荟萃分析和系统综述，以评估所有可用的随机对照试验（RCT），量化 GCE 和 CGA 干预对血糖和胰岛素水平的影响。我们在 Scopus、Web of Science 和 PubMed 数据库中进行了系统的在线检索，检索时间从建库开始至 2019 年 7 月。使用随机效应模型（Der Simonian-Laird 方法）对数据进行合并分析，并报告为加权均数差（WMD）。有 10 项试验报告了 GCE 对 FBS 和胰岛素的影响，随后纳入荟萃分析。合并结果表明，GCE 摄入后 FBS 显著改变（WMD：-1.791mg/dl，95%CI-3.404，-0.177），但研究之间无显著异质性（I =35.0%，p =0.128）。然而，总体结果表明，GCE 给药并未导致胰岛素水平发生任何显著变化（WMD：-0.925μU/ml，95%CI：-1.915，0.064），且研究间存在显著异质性（I =87.9%）。在亚组分析中，当 GCE 补充剂量≥400mg/天时，胰岛素水平显著降低（WMD：-1.942mg/dl，95%CI：-1.184，-0.975；I =0.0%）。本研究结果支持使用 GCE 来提高血糖水平，而亚组分析表明，当 GCE 补充剂量≥400mg/天时，胰岛素水平显著改善。
