Servicio de Medicina Física y Rehabilitación, Hospital La Fe, 46026 Valencia, Spain.
Grupo de Investigación en Medicina Física y Rehabilitación, Instituto de Investigación Sanitaria La Fe (IISLAFE), 46026 Valencia, Spain.
Nutrients. 2021 Nov 12;13(11):4035. doi: 10.3390/nu13114035.
Osteoarthritis (OA) is a common joint condition and one of the greatest causes of disability worldwide. The role of vitamin D in the origin and development of the disease is not clear, although it could have important implications for diagnosis and treatment. For this proposal, a cross-sectional study with a non-probabilistic sample was performed. In total, 48 with early osteoarthritis (EOA) and 48 matched controls were selected, and serum 25(OH)D and parathyroid hormone (PTH) levels were analyzed. In addition, physical and psychological variables were measured to establish their relationship with vitamin D levels. Patients with EOA showed lower levels (22.3 ± 7.3 ng/mL) in comparison to matched controls (29.31 ± 9.2 ng/mL). A statistically significant higher number (Chi-squared = 8.525; = 0.004) of patients with EOA had deficiency levels (<20 ng/mL) compared to the control group. Patients with lower vitamin D levels showed higher levels of pain intensity, disability, and anxiety, as well as poorer values for sit-to-stand, walking speed, and social participation. Correlation analysis showed a relationship between serum 25(OH)D, PTH and pain intensity, and social participation. These results highlight the relevance of vitamin D in the early diagnosis and prevention of EOA.
骨关节炎（OA）是一种常见的关节疾病，也是全球致残的主要原因之一。维生素 D 在疾病的发生和发展中的作用尚不清楚，但它可能对诊断和治疗有重要意义。在这项研究中，采用了非概率抽样的横断面研究方法。共选择了 48 例早期骨关节炎（EOA）患者和 48 例匹配的对照组，并分析了血清 25(OH)D 和甲状旁腺激素（PTH）水平。此外，还测量了身体和心理变量，以确定它们与维生素 D 水平的关系。与匹配对照组（29.31 ± 9.2ng/mL）相比，EOA 患者的血清 25(OH)D 水平明显更低（22.3 ± 7.3ng/mL）。与对照组相比，EOA 患者中缺乏维生素 D 水平（<20ng/mL）的患者数量明显更多（卡方检验 = 8.525；P=0.004）。维生素 D 水平较低的患者疼痛强度、残疾程度和焦虑程度更高，而从坐到站、行走速度和社会参与方面的评估值也更差。相关性分析显示，血清 25(OH)D 和 PTH 与疼痛强度和社会参与之间存在相关性。这些结果强调了维生素 D 在 EOA 的早期诊断和预防中的重要性。
