Herrero-Manley Luz, Alabajos-Cea Ana, Suso-Martí Luis, Cuenca-Martínez Ferran, Calatayud Joaquín, Casaña José, Viosca-Herrero Enrique, Vázquez-Arce Isabel, Ferrer-Sargues Francisco José, Blanco-Díaz María
Servicio de Medicina Física y Rehabilitación, Hospital La Fe, Valencia, Spain.
Grupo de Investigación en Medicina Física y Rehabilitación, Instituto de Investigación Sanitaria La Fe (IISLAFE), Valencia, Spain.
Front Nutr. 2023 Mar 15;10:1126796. doi: 10.3389/fnut.2023.1126796. eCollection 2023.
Osteoarthritis (OA) is a common joint condition and one of the greatest causes of disability worldwide. The role of serum lipid and inflammatory biomarkers in the origin and development of the disease is not clear, although it could have important implications for diagnosis and treatment. The primary aim of this study was to evaluate differences of serum lipid and inflammatory biomarkers with knee EOA in comparison with matched controls, in order to determine the role of these factors in the origin of EOA.
For this proposal, a cross-sectional study with a non-randomized sample was performed. 48 subjects with early osteoarthritis (EOA) and 48 matched controls were selected and serum lipid levels (total cholesterol, LDL, HDL) and inflammatory biomarkers C-reactive protein (CRP), uric acid (UA) were analyzed. In addition, clinical (pain, disability) and functional (gait speed, sit-to-stand) variables were measured to establish their relationship to serum lipid levels and inflammatory biomarkers.
Patients with EOA showed higher levels of total cholesterol LDL, UA, and CRP. Higher levels of total cholesterol, LDL and CRP were correlated with higher levels of pain intensity and higher disability ( < 0.05). In addition, UA and CRP were inversely correlated with gait speed and sit-to-stand tests ( = -0.038 to -0.5, < 0.05).
These results highlight the relevance of metabolic and proinflammatory aspects in the early stages of knee OA and could be key to developing early diagnoses to prevent the onset and development of the disease.
骨关节炎（OA）是一种常见的关节疾病，也是全球致残的主要原因之一。血清脂质和炎症生物标志物在该疾病的起源和发展中的作用尚不清楚，尽管这可能对诊断和治疗具有重要意义。本研究的主要目的是评估血清脂质和炎症生物标志物在膝部早发性骨关节炎（EOA）与匹配对照组之间的差异，以确定这些因素在EOA起源中的作用。
对于本研究，进行了一项非随机样本的横断面研究。选择了48例早发性骨关节炎（EOA）患者和48例匹配的对照组，并分析了血清脂质水平（总胆固醇、低密度脂蛋白、高密度脂蛋白）和炎症生物标志物C反应蛋白（CRP）、尿酸（UA）。此外，测量了临床（疼痛、残疾）和功能（步态速度、从坐到站）变量，以确定它们与血清脂质水平和炎症生物标志物的关系。
EOA患者的总胆固醇、低密度脂蛋白、尿酸和CRP水平较高。总胆固醇、低密度脂蛋白和CRP水平较高与疼痛强度较高和残疾程度较高相关（<0.05）。此外，尿酸和CRP与步态速度和从坐到站测试呈负相关（=-0.038至-0.5，<0.05）。
这些结果突出了代谢和促炎方面在膝骨关节炎早期阶段的相关性，可能是开发早期诊断以预防疾病发生和发展的关键。
