Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
T School of Industrial Technology, Mongolian University of Science & Technology, Ulaanbaatar 14210, Mongolia.
Nutrients. 2021 Nov 21;13(11):4175. doi: 10.3390/nu13114175.
Population-based data relating to vitamin D status of children in Northeast Asia are lacking. We conducted a cross-sectional study to determine the prevalence and determinants of vitamin D deficiency in 9595 schoolchildren aged 6-13 years in Ulaanbaatar (UB), the capital city of Mongolia. Risk factors for vitamin D deficiency were collected by questionnaire, and serum 25-hydroxyvitamin D (25[OH]D) concentrations were measured using an enzyme-linked fluorescent assay, standardized and categorized as deficient (25[OH]D <10 ng/mL) or not. Odds ratios for associations between independent variables and risk of vitamin D deficiency were calculated using multivariate analysis with adjustment for potential confounders. The prevalence of vitamins D deficiency was 40.6% (95% CI 39.7% to 41.6%). It was independently associated with female gender (adjusted odds ratio [aOR] for girls vs. boys 1.23, 95% CI 1.11-1.35), month of sampling (aORs for December-February vs. June-November 5.28 [4.53-6.15], March-May vs. June-November 14.85 [12.46-17.74]), lower levels of parental education (P for trend <0.001), lower frequency of egg consumption (P for trend <0.001), active tuberculosis (aOR 1.40 [1.03-1.94]), household smoking (aOR 1.13 [1.02 to1.25]), and shorter time outdoors (P for trend <0.001). We report a very high prevalence of vitamin D deficiency among Mongolian schoolchildren, which requires addressing as a public health priority.
东亚地区儿童维生素 D 状况的人群数据较为缺乏。我们进行了一项横断面研究,以确定蒙古乌兰巴托(UB)市 9595 名 6-13 岁学童维生素 D 缺乏症的患病率和决定因素。通过问卷调查收集维生素 D 缺乏症的危险因素,并用酶联荧光分析法测定血清 25-羟维生素 D(25[OH]D)浓度,标准化后分为缺乏(25[OH]D <10ng/ml)和不缺乏。采用多变量分析,调整潜在混杂因素后,计算独立变量与维生素 D 缺乏风险之间的比值比(OR)。维生素 D 缺乏症的患病率为 40.6%(95%CI 39.7%-41.6%)。它与女性性别(女孩与男孩的调整 OR 为 1.23,95%CI 1.11-1.35)、采样月份(12 月至 2 月与 6 月至 11 月的 OR 为 5.28[4.53-6.15],3 月至 5 月与 6 月至 11 月的 OR 为 14.85[12.46-17.74])、父母受教育程度较低(P 趋势 <0.001)、鸡蛋摄入频率较低(P 趋势 <0.001)、活动性肺结核(OR 1.40[1.03-1.94])、家庭吸烟(OR 1.13[1.02-1.25])和户外活动时间较短(P 趋势 <0.001)独立相关。我们报告了蒙古学童中维生素 D 缺乏症的极高患病率,这需要作为公共卫生重点加以解决。