Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Pakistan.
Pak J Pharm Sci. 2021 Sep;34(5(Supplementary)):1867-1872.
Mentha piperita L., a well-known traditional herb, constitutes essential oil as one of its important constituent, used for its flavor, aroma and therapeutic applications. Based on the antioxidant, antispasmodic and nephroprotective potential, the essential oil of Mentha piperita was evaluated for its preventive and curative effects against ethylene glycol induced urolithiasis. Peppermint oil (Mp.Eo) was evaluated for its antioxidant potential by DPPH method. Urolithiasis was developed in male rats by the administration of ammonium chloride and ethylene glycol in drinking water. Different doses of Mp.Eo (10, 30 and 50 mg/kg) and cystone, the standard antiurolithic drug (500 mg/kg), were given along with stone-inducing regimen in prophylactic model and after intoxication for the next fourteen days in curative model. Urine and serum were analyzed for various biochemical parameters. One representative kidney from each group was studied for changes in histological parameters. Mp.Eo was found to be effective against urolithiasis-associated changes including crystalluria, polyuria and acidic urine. Mp.Eo also neutralized the altered levels of urinary uric acid, magnesium, total protein, serum creatinine and serum BUN. The data obtained from the present study demonstrated the therapeutic importance of peppermint oil against urolithiasis.
胡椒薄荷（Mentha piperita L.）是一种广为人知的传统草本植物，其重要组成部分之一是精油，因其风味、香气和治疗用途而被广泛使用。基于抗氧化、抗痉挛和肾保护的潜力，评估了胡椒薄荷精油预防和治疗乙二醇诱导的尿路结石的效果。通过 DPPH 法评估薄荷油（Mp.Eo）的抗氧化潜力。通过在饮用水中给予氯化铵和乙二醇在雄性大鼠中诱导尿石症。在预防性模型中，给予不同剂量的 Mp.Eo（10、30 和 50mg/kg）和标准抗结石药物胱氨酸（500mg/kg），并与结石诱导方案一起给药，在治疗性模型中在中毒后给药 14 天。分析尿液和血清中的各种生化参数。每组取一个代表性肾脏，研究其组织学参数的变化。Mp.Eo 对结石相关变化（包括结晶尿、多尿和酸性尿）有效。Mp.Eo 还中和了尿液尿酸、镁、总蛋白、血清肌酐和血清 BUN 的改变水平。本研究获得的数据表明，薄荷油对尿路结石具有治疗重要性。
