School of Dentistry, The University of Queensland, Brisbane, Queensland, 4066, Australia.
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia.
Angew Chem Int Ed Engl. 2022 Mar 14;61(12):e202112752. doi: 10.1002/anie.202112752. Epub 2022 Feb 1.
Recently, dendritic mesoporous silica nanoparticles with widespread applications have attracted great interest. Despite many publications (>800), the terminology "dendritic" is ambiguous. Understanding what possible "dendritic structures" are, their formation mechanisms and the underlying structure-property relationship is fundamentally important. With the advance of characterization techniques such as electron tomography, two types of tree-branch-like and flower-like structures can be distinguished, both described as "dendritic" in the literature. In this Review, we start with the definition of "dendritic", then provide critical analysis of reported dendritic silica nanoparticles according to their structural classification. We update the understandings of the formation mechanisms of two types of "dendritic" nanoparticles, highlighting how to control their structural parameters. Applications of dendritic mesoporous nanoparticles are also reviewed with a focus on the biomedical field, providing new insights into the structure-property relationship in this family of nanomaterials.
最近，具有广泛应用的树枝状介孔硅纳米粒子引起了极大的兴趣。尽管有许多出版物（>800 篇），但“树枝状”一词的含义仍不明确。理解可能存在的“树枝状结构”、它们的形成机制以及潜在的结构-性质关系至关重要。随着电子断层扫描等表征技术的进步，可以区分出两种树枝状和花状结构，在文献中都被描述为“树枝状”。在这篇综述中，我们首先从“树枝状”的定义开始，然后根据结构分类对报道的树枝状硅纳米粒子进行批判性分析。我们更新了对两种“树枝状”纳米粒子形成机制的理解，强调了如何控制它们的结构参数。还综述了树枝状介孔纳米粒子的应用，重点关注生物医学领域，为这组纳米材料的结构-性质关系提供了新的见解。
