Department of Civil Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, India.
Environ Sci Pollut Res Int. 2022 Apr;29(17):25046-25059. doi: 10.1007/s11356-021-17308-6. Epub 2021 Nov 27.
This study estimated health risks due to two types of copper-based nanoagrochemicals (Cu (OH) and CuO nanoparticles (NPs)), during inadvertent ingestion of soil and consumption of leafy vegetables for a hypothetical exposure scenario. The dissolution of copper-based nanoagrochemicals in human digestive system was considered for estimating realistic doses. No risk was found during soil ingestion (hazard quotient (HQ) <1). HQ (no dissolution of Cu (OH) nanopesticides) (HQ= 0.015) comes out to be 2 times higher than that of HQ (100% dissolution of Cu (OH) nanopesticides into copper ions) (HQ= 0.007). In case of risk from consumption of leafy vegetables, the following order of risk was found (high to low HQ value): Cu (OH) (HQ= 1925) >CuO NPs (1402). Combined exposure of Cu (OH) nanopesticide through soil ingestion as well as consumption of contaminated edible leafy vegetables resulted in health risks. The calculated maximum allowable applicable concentration values of Cu (OH) and CuO NPs without posing risk to human and plant toxicity were found to be 1.14 and 0.45 mg/L, respectively. These findings can be used now for deciding safe use of copper-based nanoagrochemicals.
本研究估算了在误吞土壤和食用叶菜类蔬菜的假设暴露情景下，两种铜基纳米农用化学品（Cu（OH）和 CuO 纳米颗粒（NPs））造成的健康风险。考虑了铜基纳米农用化学品在人体消化系统中的溶解情况，以估算实际剂量。在摄入土壤时未发现风险（危害商数（HQ）<1）。HQ（不溶解 Cu（OH）纳米农药）（HQ=0.015）比 HQ（100%溶解 Cu（OH）纳米农药成铜离子）（HQ=0.007）高 2 倍。在食用叶菜类蔬菜的风险方面，发现以下风险顺序（HQ 值从高到低）：Cu（OH）（HQ=1925）>CuO NPs（1402）。通过土壤摄入以及食用受污染的可食用叶菜类蔬菜，同时接触 Cu（OH）纳米农药，会对健康造成风险。计算出在不引起人类和植物毒性风险的情况下，Cu（OH）和 CuO NPs 的最大允许适用浓度值分别为 1.14 和 0.45 mg/L。这些发现可用于决定铜基纳米农用化学品的安全使用。
