Department of Biological Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), Cristóvão Colombo 2265 Street, Jardim Nazareth, 15054-000, São José Do Rio Preto, São Paulo, Brazil.
Department of Biological Sciences, Institute of Biosciences, Humanities and Exact Sciences, São Paulo State University (UNESP), Cristóvão Colombo 2265 Street, Jardim Nazareth, 15054-000, São José Do Rio Preto, São Paulo, Brazil.
Food Chem Toxicol. 2021 Dec;158:112700. doi: 10.1016/j.fct.2021.112700. Epub 2021 Nov 25.
Bisphenol A (BPA) is a chemical agent which can exert detrimental effects on the male reproductive system, especially the prostate gland. In this study we described the efficacy of the dietary agent curcumin, alone or combined with piperine, to suppress the impact of BPA on the prostate. Adult gerbils were divided into nine experimental groups (n = 7 each group), regarding control (water and oil), exposed to BPA (50 μg/kg/day in water) or curcumin (100 mg/kg) and/or piperine (20 mg/kg). To evaluate the effects of the phytotherapic agents, the other groups received oral doses every two days, BPA plus curcumin (BCm), piperine (BP), and curcumin + piperine (BCmP). BPA promoted prostatic inflammation and morphological lesions in ventral and dorsolateral prostate lobes, associated with an increase in androgen receptor-positive cells and nuclear atypia, mainly in the ventral lobe. Curcumin and piperine helped to minimize these effects. BPA plus piperine or curcumin showed a reduction in nuclear atypical phenotype, indicating a beneficial effect of phytochemicals. Thus, these phytochemicals minimize the deleterious action of BPA in prostatic lobes, especially when administered in association. The protective action of curcumin and piperine consumption is associated with weight loss, anti-inflammatory potential, and control of prostate epithelial cell homeostasis.
双酚 A（BPA）是一种化学物质，它对男性生殖系统，特别是前列腺有不良影响。在这项研究中，我们描述了膳食补充剂姜黄素，单独或与胡椒碱联合使用，以抑制 BPA 对前列腺的影响的功效。成年沙鼠分为九个实验组（每组 n=7），对照组（水和油）、暴露于 BPA（水中 50μg/kg/天）或姜黄素（100mg/kg）和/或胡椒碱（20mg/kg）。为了评估植物治疗剂的作用，其他组每两天口服一次剂量，BPA 加姜黄素（BCm）、胡椒碱（BP）和姜黄素+胡椒碱（BCmP）。BPA 促进了前列腺的炎症和形态学病变，包括腹侧和背外侧前列腺叶，与雄激素受体阳性细胞和核异型性增加有关，主要在腹侧叶。姜黄素和胡椒碱有助于减少这些影响。BPA 加胡椒碱或姜黄素可减少核异型表型，表明植物化学物质具有有益作用。因此，这些植物化学物质最大限度地减少了 BPA 在前列腺叶中的有害作用，尤其是在联合使用时。姜黄素和胡椒碱的保护作用与体重减轻、抗炎潜力和控制前列腺上皮细胞稳态有关。
