Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200217, China.
Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200217, China; Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
Drug Discov Today. 2022 Apr;27(4):1196-1203. doi: 10.1016/j.drudis.2021.11.019. Epub 2021 Nov 24.
Immuno-positron emission tomography (immunoPET) imaging is a paradigm-shifting imaging technique for whole-body and all-lesion tumor detection, based on the combined specificity of tumor-targeting vectors [e.g., monoclonal antibodies (mAbs), nanobodies, and bispecific antibodies] and the sensitivity of PET imaging. By noninvasively, comprehensively, and serially revealing heterogeneous tumor antigen expression, immunoPET imaging is gradually improving the theranostic prospects for hematological malignancies. In this review, we summarize the available literature regarding immunoPET in imaging hematological malignancies. We also highlight the pros and cons of current conjugation strategies, and modular chemistry that can be leveraged to develop novel immunoPET probes for hematological malignancies. Lastly, we discuss the use of immunoPET imaging in guiding antibody drug development.
免疫正电子发射断层扫描（immunoPET）成像技术是一种基于肿瘤靶向载体（如单克隆抗体（mAbs）、纳米抗体和双特异性抗体）的特异性和正电子发射断层扫描成像的敏感性的全身和所有病变肿瘤检测的颠覆性成像技术。通过非侵入性、全面和连续地揭示异质性肿瘤抗原表达，immunoPET 成像正在逐渐改善血液系统恶性肿瘤的治疗前景。在这篇综述中，我们总结了有关 immunoPET 成像血液系统恶性肿瘤的现有文献。我们还强调了当前结合策略的优缺点，以及可以利用的模块化化学来开发用于血液系统恶性肿瘤的新型 immunoPET 探针。最后，我们讨论了 immunoPET 成像在指导抗体药物开发中的应用。
