Department of Ophthalmology, Saarland University Medical Center (UKS), Homburg, Germany .
Cornea. 2022 Apr 1;41(4):518-537. doi: 10.1097/ICO.0000000000002937.
The aims of this meta-analysis were to evaluate the results of intracorneal ring segments (ICRSs) and MyoRing in the management of corneal ectasia and to compare the clinical outcomes and complication rates between mechanical and femtosecond (FS) laser-assisted surgery.
An online electronic search was performed for pre-post studies published until April 2020. Uncorrected distance visual acuity, corrected distance visual acuity, sphere, cylinder, spherical equivalent, steep, flat, and mean keratometry values were considered as outcomes. Weighted mean difference with 95% confidence interval was used as a pooled estimation of intervention efficacy.
Of 1484 potentially related studies, 115 studies were finally included in the meta-analysis. Findings of this meta-analysis demonstrated considerable improvement in visual, refractive, and keratometric outcomes in all ICRS models and MyoRing. Intrastromal tunnel creation with both methods yielded similar results. Complication rates were without exception higher when mechanical dissection was used.
ICRS and MyoRing are appropriate treatment options for patients with corneal ectasia. Both techniques for tunnel creation are efficacious in achieving good visual, keratometric, and refractive results. Mechanical intrastromal tunnel creation is associated with much higher complication rates when compared with FS laser-assisted technique.
本荟萃分析旨在评估角膜环段(ICRS)和 MyoRing 在角膜扩张症治疗中的结果,并比较机械和飞秒(FS)激光辅助手术的临床结果和并发症发生率。
对截至 2020 年 4 月发表的前瞻性和回顾性研究进行了在线电子检索。未矫正的远视力、矫正的远视力、球镜、柱镜、等效球镜、陡峭值、平坦值和平均角膜曲率值被视为结果。采用加权均数差及其 95%置信区间作为干预效果的汇总估计值。
在 1484 项潜在相关研究中,最终有 115 项研究纳入荟萃分析。荟萃分析的结果表明,所有 ICRS 模型和 MyoRing 均能显著改善视力、屈光和角膜曲率。两种方法的基质内隧道创建均产生相似的结果。机械分离时,并发症发生率无一例外更高。
ICRS 和 MyoRing 是治疗角膜扩张症患者的合适选择。两种隧道创建技术在获得良好的视力、角膜曲率和屈光结果方面均有效。与 FS 激光辅助技术相比,机械基质内隧道创建的并发症发生率更高。