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角膜切口挛缩:文献综述及使用角膜基质内环形片段的新型治疗策略报告

Corneal incision contracture: literature review and report of a novel therapeutic strategy using intrastromal corneal ring segments.

作者信息

Prados-Carmona Juan J, Arias-Alcalá Manuel, Prados-Carmona Álvaro, Herrador-Montiel M Ángeles, Hernando-Molina María, Giménez-Almenara-Amo Javier

机构信息

Department of Ophthalmology, Reina Sofía University Hospital, Avenida Menéndez Pidal, s/n, 14004, Córdoba, Spain.

Department of Dermatology, Hospital Universitario San Cecilio, Avenida de la Ilustración S/N, 18016, Granada, Spain.

出版信息

Int Ophthalmol. 2025 May 5;45(1):171. doi: 10.1007/s10792-025-03551-0.

Abstract

PURPOSE

This review summarizes key aspects of corneal incision contracture (CIC), also known as wound burn. CIC is a rare complication of phacoemulsification, which can significantly compromise surgical outcomes, leading to delayed healing, suboptimal functional results, and patient dissatisfaction.

METHODS

A comprehensive literature review was conducted across multiple databases, encompassing full-length studies, case series, and reports. A total of 52 studies were selected, focusing either on the etiopathogenesis and risk factors of CIC or on different treatment strategies.

RESULTS

Although preventing CIC remains challenging, key risk factors include excessive ultrasound energy, the use of high-viscosity ophthalmic viscosurgical devices (OVDs), and narrower, longer incisions, particularly in shallow anterior chambers. Additionally, this review highlights therapeutic approaches for managing both the acute and chronic phases of CIC. A critical analysis of previous reports reveals a lack of consensus on management and limited attention to long-term rehabilitation, contributing to suboptimal visual outcomes in the majority of patients. Finally, we propose a novel treatment for the chronic phase of CIC: the implantation of intracorneal ring segments (ICRS), a technique not previously described. This method was successfully applied in a patient with severe CIC-induced astigmatism (> 23 diopters), achieving a plano spherical equivalent and a final visual acuity (VA) of 0.8 decimal (0.1 logMAR). This outcome surpasses those reported in previous literature.

CONCLUSION

This study highlights the significant challenges associated with CIC and introduces a promising therapeutic strategy using ICRS implantation, potentially improving outcomes for these complex cases.

摘要

目的

本综述总结了角膜切口挛缩(CIC)(也称为伤口烧伤)的关键方面。CIC是白内障超声乳化术的一种罕见并发症,可显著影响手术效果,导致愈合延迟、功能结果不理想以及患者不满。

方法

对多个数据库进行了全面的文献综述,涵盖全文研究、病例系列和报告。共筛选出52项研究,重点关注CIC的病因发病机制和危险因素或不同的治疗策略。

结果

尽管预防CIC仍然具有挑战性,但关键危险因素包括超声能量过高、使用高粘度眼科粘弹剂(OVD)以及更窄、更长的切口,尤其是在前房较浅的情况下。此外,本综述强调了CIC急性期和慢性期的治疗方法。对既往报告的批判性分析表明,在治疗方面缺乏共识,对长期康复的关注有限,导致大多数患者的视觉效果不理想。最后,我们提出了一种针对CIC慢性期的新治疗方法:植入角膜内环片(ICRS),这是一种此前未描述过的技术。该方法成功应用于一名患有严重CIC诱导散光(>23屈光度)的患者,实现了等效球镜度为零,最终视力(VA)为小数视力0.8(logMAR为0.1)。这一结果超过了既往文献报道的结果。

结论

本研究强调了与CIC相关的重大挑战,并引入了一种有前景的治疗策略——ICRS植入,可能改善这些复杂病例的治疗效果。

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